OBJECTIVE: To evaluate a comprehensive multislice computed tomography (MSCT) protocol in patients with previous infarction, including assessment of coronary artery stenoses, left ventricular (LV) function and perfusion. PATIENTS AND METHODS: 16-slice MSCT was performed in 21 patients with previous infarction; from the MSCT data, coronary artery stenoses, (regional and global) LV function and perfusion were assessed. Invasive coronary angiography and gated single-photon emission computed tomography (SPECT) served as the reference standards for coronary artery stenoses and LV function/perfusion, respectively. RESULTS: 236 of 241 (98%) coronary artery segments were interpretable on MSCT. The sensitivity and specificity for detection of stenoses were 91% and 97%. Pearson's correlation showed excellent agreement for assessment of LV ejection fraction between MSCT and SPECT (49 (13)% v 53 (12)%, respectively, r = 0.85). Agreement for assessment of regional wall motion was excellent (92%, kappa = 0.77). In 68 of 73 (93%) segments, MSCT correctly identified a perfusion defect as compared with SPECT, whereas the absence of perfusion defects was correctly detected in 277 of 284 (98%) segments. CONCLUSIONS: MSCT permits accurate, non-invasive assessment of coronary artery stenoses, LV function and perfusion in patients with previous infarction. All parameters can be assessed from a single dataset.
OBJECTIVE: To evaluate a comprehensive multislice computed tomography (MSCT) protocol in patients with previous infarction, including assessment of coronary artery stenoses, left ventricular (LV) function and perfusion. PATIENTS AND METHODS: 16-slice MSCT was performed in 21 patients with previous infarction; from the MSCT data, coronary artery stenoses, (regional and global) LV function and perfusion were assessed. Invasive coronary angiography and gated single-photon emission computed tomography (SPECT) served as the reference standards for coronary artery stenoses and LV function/perfusion, respectively. RESULTS: 236 of 241 (98%) coronary artery segments were interpretable on MSCT. The sensitivity and specificity for detection of stenoses were 91% and 97%. Pearson's correlation showed excellent agreement for assessment of LV ejection fraction between MSCT and SPECT (49 (13)% v 53 (12)%, respectively, r = 0.85). Agreement for assessment of regional wall motion was excellent (92%, kappa = 0.77). In 68 of 73 (93%) segments, MSCT correctly identified a perfusion defect as compared with SPECT, whereas the absence of perfusion defects was correctly detected in 277 of 284 (98%) segments. CONCLUSIONS: MSCT permits accurate, non-invasive assessment of coronary artery stenoses, LV function and perfusion in patients with previous infarction. All parameters can be assessed from a single dataset.
Authors: Manuel D Cerqueira; Neil J Weissman; Vasken Dilsizian; Alice K Jacobs; Sanjiv Kaul; Warren K Laskey; Dudley J Pennell; John A Rumberger; Thomas Ryan; Mario S Verani Journal: Circulation Date: 2002-01-29 Impact factor: 29.690
Authors: S Achenbach; T Giesler; D Ropers; S Ulzheimer; H Derlien; C Schulte; E Wenkel; W Moshage; W Bautz; W G Daniel; W A Kalender; U Baum Journal: Circulation Date: 2001-05-29 Impact factor: 29.690
Authors: W G Austen; J E Edwards; R L Frye; G G Gensini; V L Gott; L S Griffith; D C McGoon; M L Murphy; B B Roe Journal: Circulation Date: 1975-04 Impact factor: 29.690
Authors: Joanne D Schuijf; Jeroen J Bax; J Wouter Jukema; Hildo J Lamb; Hubert W Vliegen; Liesbeth P Salm; Albert de Roos; Ernst E van der Wall Journal: Diabetes Care Date: 2004-12 Impact factor: 19.112
Authors: Joanne D Schuijf; Jeroen J Bax; Liesbeth P Salm; J Wouter Jukema; Hildo J Lamb; Ernst E van der Wall; Albert de Roos Journal: Am J Cardiol Date: 2005-03-01 Impact factor: 2.778
Authors: Konstantin Nikolaou; Javier Sanz; Michael Poon; Bernd J Wintersperger; Bernd Ohnesorge; Teresa Rius; Zahi A Fayad; Maximilian F Reiser; Christoph R Becker Journal: Eur Radiol Date: 2005-03-18 Impact factor: 5.315
Authors: Andreas H Mahnken; Ralf Koos; Marcus Katoh; Joachim E Wildberger; Elmar Spuentrup; Arno Buecker; Rolf W Günther; Harald P Kühl Journal: J Am Coll Cardiol Date: 2005-06-21 Impact factor: 24.094
Authors: G Germano; H Kiat; P B Kavanagh; M Moriel; M Mazzanti; H T Su; K F Van Train; D S Berman Journal: J Nucl Med Date: 1995-11 Impact factor: 10.057
Authors: Andreas H Mahnken; Ralf Koos; Marcus Katoh; Elmar Spuentrup; Petra Busch; Joachim E Wildberger; Harald P Kühl; Rolf W Günther Journal: Eur Radiol Date: 2005-01-29 Impact factor: 5.315
Authors: Nadjia Kachenoura; Joseph A Lodato; Tamar Gaspar; Dianna M E Bardo; Barbara Newby; Sarah Gips; Nathan Peled; Roberto M Lang; Victor Mor-Avi Journal: Eur Radiol Date: 2009-03-12 Impact factor: 5.315
Authors: Kelley R Branch; Janet Busey; Lee M Mitsumori; Jared Strote; James H Caldwell; Joshua H Busch; William P Shuman Journal: AJR Am J Roentgenol Date: 2013-05 Impact factor: 3.959
Authors: Nadjia Kachenoura; Federico Veronesi; Joseph A Lodato; Cristiana Corsi; Rupa Mehta; Barbara Newby; Roberto M Lang; Victor Mor-Avi Journal: Eur Radiol Date: 2009-08-27 Impact factor: 5.315