Literature DB >> 16707707

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.

Chunhua Zhao1, Jianhua Ju, Steven D Christenson, Wyatt C Smith, Danfeng Song, Xiufen Zhou, Ben Shen, Zixin Deng.   

Abstract

Oxazolomycin (OZM), a hybrid peptide-polyketide antibiotic, exhibits potent antitumor and antiviral activities. Using degenerate primers to clone genes encoding methoxymalonyl-acyl carrier protein (ACP) biosynthesis as probes, a 135-kb DNA region from Streptomyces albus JA3453 was cloned and found to cover the entire OZM biosynthetic gene cluster. The involvement of the cloned genes in OZM biosynthesis was confirmed by deletion of a 12-kb DNA fragment containing six genes for methoxymalonyl-ACP biosynthesis from the specific region of the chromosome, as well as deletion of the ozmC gene within this region, to generate OZM-nonproducing mutants.

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Year:  2006        PMID： 16707707      PMCID： PMC1482894          DOI： 10.1128/JB.00173-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase.

Authors:  B Shen; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

2.  New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.

Authors:  K Shiomi; N Arai; M Shinose; Y Takahashi; H Yoshida; J Iwabuchi; Y Tanaka; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1995-07       Impact factor: 2.649

3.  Novel bioactive oxazolomycin isomers produced by Streptomyces albus JA3453.

Authors:  H Kanzaki; K Wada; T Nitoda; K Kawazu
Journal:  Biosci Biotechnol Biochem       Date:  1998-03       Impact factor: 2.043

4.  Structure of a new antibiotic curromycin A produced by a genetically modified strain of Streptomyces hygroscopicus, a polyether antibiotic producing organism.

Authors:  M Ogura; H Nakayama; K Furihata; A Shimazu; H Seto; N Otake
Journal:  J Antibiot (Tokyo)       Date:  1985-05       Impact factor: 2.649

5.  Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis.

Authors:  W Bao; P J Sheldon; C R Hutchinson
Journal:  Biochemistry       Date:  1999-07-27       Impact factor: 3.162

6.  Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

Authors:  Rama Rao Manam; Sy Teisan; Donald J White; Benjamin Nicholson; Jennifer Grodberg; Saskia T C Neuteboom; Kin S Lam; Deborah A Mosca; G Kenneth Lloyd; Barbara C M Potts
Journal:  J Nat Prod       Date:  2005-02       Impact factor: 4.050

7.  Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

Authors:  Andreas Rascher; Zhihao Hu; Nina Viswanathan; Andreas Schirmer; Ralph Reid; William C Nierman; Matthew Lewis; C Richard Hutchinson
Journal:  FEMS Microbiol Lett       Date:  2003-01-28       Impact factor: 2.742

8.  Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.

Authors:  Wenli Li; Jianhua Ju; Hiroyuki Osada; Ben Shen
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

9.  The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Authors:  K Wu; L Chung; W P Revill; L Katz; C D Reeves
Journal:  Gene       Date:  2000-06-13       Impact factor: 3.688

10.  New triene-beta-lactone antibiotics, triedimycins A and B.

Authors:  Y Ikeda; S Kondo; H Naganawa; S Hattori; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1991-04       Impact factor: 2.649
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  16 in total

Review 1.  Biosynthesis of polyketide synthase extender units.

Authors:  Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal:  Nat Prod Rep       Date:  2009-01       Impact factor: 13.423

2.  Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.

Authors:  Yunlong He; Yuhui Sun; Tiangang Liu; Xiufen Zhou; Linquan Bai; Zixin Deng
Journal:  Appl Environ Microbiol       Date:  2010-03-26       Impact factor: 4.792

3.  The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.

Authors:  Drew A Vander Wood; Adrian T Keatinge-Clay
Journal:  Proteins       Date:  2018-03-25

4.  Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units.

Authors:  Chunhua Zhao; Jane M Coughlin; Jianhua Ju; Dongqing Zhu; Evelyn Wendt-Pienkowski; Xiufen Zhou; Zhijun Wang; Ben Shen; Zixin Deng
Journal:  J Biol Chem       Date:  2010-04-20       Impact factor: 5.157

5.  Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.

Authors:  Wenli Li; Jianhua Ju; Hiroyuki Osada; Ben Shen
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

Review 6.  The oxazolomycin family: a review of current knowledge.

Authors:  Patrik Oleksak; Jozef Gonda; Eugenie Nepovimova; Kamil Kuca; Kamil Musilek
Journal:  RSC Adv       Date:  2020-11-09       Impact factor: 4.036

Review 7.  Antitumor compounds from marine actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Mar Drugs       Date:  2009-06-11       Impact factor: 5.118

8.  Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.

Authors:  Yongjun Zhou; Qingqing Meng; Delin You; Jialiang Li; Shi Chen; Dazhong Ding; Xiufen Zhou; Huchen Zhou; Linquan Bai; Zixin Deng
Journal:  Appl Environ Microbiol       Date:  2008-10-03       Impact factor: 4.792

9.  Biosynthesis Gene Cluster and Oxazole Ring Formation Enzyme for Inthomycins in Streptomyces sp. Strain SYP-A7193.

Authors:  Shao-Yang Hou; Meng-Yue Zhang; Hong-Da Wang; Yi-Xuan Zhang
Journal:  Appl Environ Microbiol       Date:  2020-10-01       Impact factor: 4.792

10.  Type I polyketide synthases that require discrete acyltransferases.

Authors:  Yi-Qiang Cheng; Jane M Coughlin; Si-Kyu Lim; Ben Shen
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600
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