Literature DB >> 12586396

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

Andreas Rascher1, Zhihao Hu, Nina Viswanathan, Andreas Schirmer, Ralph Reid, William C Nierman, Matthew Lewis, C Richard Hutchinson.   

Abstract

We illustrate the use of a PCR-based method by which the genomic DNA of a microorganism can be rapidly queried for the presence of type I modular polyketide synthase genes to clone and characterize, by sequence analysis and gene disruption, a major portion of the geldanamycin production gene cluster from Streptomyces hygroscopicus var. geldanus NRRL 3602.

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Year:  2003        PMID： 12586396     DOI： 10.1016/S0378-1097(02)01148-5

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  42 in total

1.  Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus.

Authors:  Eun Young Kim; Jae Woo Han; Jee Yeon Lee; Beom Seok Kim
Journal:  Folia Microbiol (Praha)       Date:  2012-06-06       Impact factor: 2.099

2.  Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

Authors:  Kirsten Harmrolfs; Marco Brünjes; Gerald Dräger; Heinz G Floss; Florenz Sasse; Florian Taft; Andreas Kirschning
Journal:  Chembiochem       Date:  2010-12-10       Impact factor: 3.164

3.  The evolution of gene collectives: How natural selection drives chemical innovation.

Authors:  Michael A Fischbach; Christopher T Walsh; Jon Clardy
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-23       Impact factor: 11.205

Review 4.  Biosynthesis of polyketide synthase extender units.

Authors:  Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal:  Nat Prod Rep       Date:  2009-01       Impact factor: 13.423

Review 5.  Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

Authors:  Briana J Dunn; Chaitan Khosla
Journal:  J R Soc Interface       Date:  2013-05-29       Impact factor: 4.118

6.  RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei.

Authors:  Chen Li; Xinqiang Liu; Chao Lei; Han Yan; Zhihui Shao; Ying Wang; Guoping Zhao; Jin Wang; Xiaoming Ding
Journal:  Appl Environ Microbiol       Date:  2017-03-31       Impact factor: 4.792

7.  Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation.

Authors:  Leandro Vetcher; Zong-Qiang Tian; Robert McDaniel; Andreas Rascher; W Peter Revill; C Richard Hutchinson; Zhihao Hu
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

8.  Comparison of cyanopeptolin genes in Planktothrix, Microcystis, and Anabaena strains: evidence for independent evolution within each genus.

Authors:  Trine B Rounge; Thomas Rohrlack; Ave Tooming-Klunderud; Tom Kristensen; Kjetill S Jakobsen
Journal:  Appl Environ Microbiol       Date:  2007-10-05       Impact factor: 4.792

9.  Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

Authors:  Hua Zhang; Jess A White-Phillip; Charles E Melançon; Hyung-jin Kwon; Wei-luen Yu; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2007-11-07       Impact factor: 15.419

10.  Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

Authors:  Gitanjali Yadav; Rajesh S Gokhale; Debasisa Mohanty
Journal:  PLoS Comput Biol       Date:  2009-04-10       Impact factor: 4.475
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