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Literature DB >> 15730252

Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

Rama Rao Manam¹, Sy Teisan, Donald J White, Benjamin Nicholson, Jennifer Grodberg, Saskia T C Neuteboom, Kin S Lam, Deborah A Mosca, G Kenneth Lloyd, Barbara C M Potts.

Abstract

A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.

Entities: Chemical Disease Species

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Year: 2005 PMID： 15730252 DOI： 10.1021/np049725x

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

21 in total

1. Larvicidal activity of isolated compound 5-(2,4-dimethylbenzyl) pyrrolidin-2-one from marine Streptomyces VITSVK5 sp. against Rhipicephalus (Boophilus) microplus, Anopheles stephensi, and Culex tritaeniorhynchus.

Authors: Kumar Saurav; Govindasamy Rajakumar; Krishnan Kannabiran; Abdul Abdul Rahuman; Kanayairam Velayutham; Gandhi Elango; Chinnaperumal Kamaraj; Abdul Abduz Zahir
Journal: Parasitol Res Date: 2011-10-19 Impact factor: 2.289

2. Research on marine actinobacteria in India.

Authors: K Sivakumar; Maloy Kumar Sahu; T Thangaradjou; L Kannan
Journal: Indian J Microbiol Date: 2007-10-04 Impact factor: 2.461

3. Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada.

Authors: K R Duncan; B Haltli; K A Gill; H Correa; F Berrué; R G Kerr
Journal: J Ind Microbiol Biotechnol Date: 2014-11-05 Impact factor: 3.346

4. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.

Authors: Chunhua Zhao; Jianhua Ju; Steven D Christenson; Wyatt C Smith; Danfeng Song; Xiufen Zhou; Ben Shen; Zixin Deng
Journal: J Bacteriol Date: 2006-06 Impact factor: 3.490

5. Antimicrobial potential of deep surface sediment associated bacteria from the Sea of Japan.

Authors: Lyudmila A Romanenko; Naoto Tanaka; Natalia I Kalinovskaya; Valery V Mikhailov
Journal: World J Microbiol Biotechnol Date: 2013-02-06 Impact factor: 3.312

6. Anti-methicillin Resistant Staphylococcus aureus Compound Isolation from Halophilic Bacillus amyloliquefaciens MHB1 and Determination of Its Mode of Action Using Electron Microscope and Flow Cytometry Analysis.

Authors: Venkadapathi Jeyanthi; Palaniyandi Velusamy
Journal: Indian J Microbiol Date: 2016-01-30 Impact factor: 2.461

Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

1. Larvicidal activity of isolated compound 5-(2,4-dimethylbenzyl) pyrrolidin-2-one from marine Streptomyces VITSVK5 sp. against Rhipicephalus (Boophilus) microplus, Anopheles stephensi, and Culex tritaeniorhynchus.

2. Research on marine actinobacteria in India.

3. Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada.

4. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.

5. Antimicrobial potential of deep surface sediment associated bacteria from the Sea of Japan.

6. Anti-methicillin Resistant Staphylococcus aureus Compound Isolation from Halophilic Bacillus amyloliquefaciens MHB1 and Determination of Its Mode of Action Using Electron Microscope and Flow Cytometry Analysis.

Review 7. Antitumor compounds from marine actinomycetes.

8. Synthesis of a library of "lead-like" γ-lactams by a one pot, four-component reaction.

Review 9. Antimicrobial compounds from marine actinomycetes.

10. Systematic and biotechnological aspects of halophilic and halotolerant actinomycetes.