Literature DB >> 16707708

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.

Wenli Li1, Jianhua Ju, Hiroyuki Osada, Ben Shen.   

Abstract

Tautomycin (TTM), a potent protein phosphatase inhibitor, consists of a polyketide chain containing a spiroketal moiety and an acyl chain bearing a dialkylmaleic anhydride structure. PCR using degenerate primers was used to clone genes from Streptomyces spiroverticillatus for formation of the methoxymalonyl-acyl carrier protein. This locus was found to contain five genes (ttmC, ttmA, ttmD, ttmB, and ttmE), one of which was used as a probe to clone the 110-kb TTM biosynthetic gene cluster. The involvement of the ttmA gene in TTM biosynthesis was confirmed by gene inactivation and mutation complementation experiments.

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Year:  2006        PMID： 16707708      PMCID： PMC1482887          DOI： 10.1128/JB.00172-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

1.  An efficient approach for screening minimal PKS genes from Streptomyces.

Authors:  M Metsä-Ketelä; V Salo; L Halo; A Hautala; J Hakala; P Mäntsälä; K Ylihonko
Journal:  FEMS Microbiol Lett       Date:  1999-11-01       Impact factor: 2.742

2.  Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase.

Authors:  B Shen; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

3.  Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences.

Authors:  T M Rose; E R Schultz; J G Henikoff; S Pietrokovski; C M McCallum; S Henikoff
Journal:  Nucleic Acids Res       Date:  1998-04-01       Impact factor: 16.971

4.  Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.

Authors:  J Magae; C Watanabe; H Osada; X C Cheng; K Isono
Journal:  J Antibiot (Tokyo)       Date:  1988-07       Impact factor: 2.649

5.  A new antibiotic, tautomycetin.

Authors:  X C Cheng; T Kihara; X Ying; M Uramoto; H Osada; H Kusakabe; B N Wang; Y Kobayashi; K Ko; I Yamaguchi
Journal:  J Antibiot (Tokyo)       Date:  1989-01       Impact factor: 2.649

6.  The structure of tautomycetin, a dialkylmaleic anhydride antibiotic.

Authors:  X C Cheng; M Ubukata; K Isono
Journal:  J Antibiot (Tokyo)       Date:  1990-07       Impact factor: 2.649

7.  Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A.

Authors:  C MacKintosh; S Klumpp
Journal:  FEBS Lett       Date:  1990-12-17       Impact factor: 4.124

8.  Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.

Authors:  Chunhua Zhao; Jianhua Ju; Steven D Christenson; Wyatt C Smith; Danfeng Song; Xiufen Zhou; Ben Shen; Zixin Deng
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

9.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Authors:  M Bierman; R Logan; K O'Brien; E T Seno; R N Rao; B E Schoner
Journal:  Gene       Date:  1992-07-01       Impact factor: 3.688

10.  Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein.

Authors:  A Takai; K Sasaki; H Nagai; G Mieskes; M Isobe; K Isono; T Yasumoto
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857
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  11 in total

Review 1.  Biosynthesis of polyketide synthase extender units.

Authors:  Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal:  Nat Prod Rep       Date:  2009-01       Impact factor: 13.423

Review 2.  Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.

Authors:  Si-Sun Choi; Hee-Ju Nah; Hye-Rim Pyeon; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2016-10-12       Impact factor: 3.346

3.  Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units.

Authors:  Chunhua Zhao; Jane M Coughlin; Jianhua Ju; Dongqing Zhu; Evelyn Wendt-Pienkowski; Xiufen Zhou; Zhijun Wang; Ben Shen; Zixin Deng
Journal:  J Biol Chem       Date:  2010-04-20       Impact factor: 5.157

4.  Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.

Authors:  Chunhua Zhao; Jianhua Ju; Steven D Christenson; Wyatt C Smith; Danfeng Song; Xiufen Zhou; Ben Shen; Zixin Deng
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

5.  Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.

Authors:  Wenli Li; Jianhua Ju; Scott R Rajski; Hiroyuki Osada; Ben Shen
Journal:  J Biol Chem       Date:  2008-08-15       Impact factor: 5.157

6.  Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Authors:  Wei Zhang; Jeffrey L Fortman; Jacob C Carlson; Jinyong Yan; Yi Liu; Fali Bai; Wenna Guan; Junyong Jia; Teatulohi Matainaho; David H Sherman; Shengying Li
Journal:  Chembiochem       Date:  2013-01-29       Impact factor: 3.164

7.  Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.

Authors:  Scott N Pinchot; Joel T Adler; Yinggang Luo; Jianhua Ju; Wenli Li; Ben Shen; Muthusamy Kunnimalaiyaan; Herbert Chen
Journal:  Am J Surg       Date:  2009-03       Impact factor: 2.565

8.  Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis.

Authors:  Sanghyun Lee; Jihoon Kang; Jungwook Kim
Journal:  Sci Rep       Date:  2019-05-30       Impact factor: 4.379

9.  Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron.

Authors:  Caroline E Moore; Pamela J Lein; Birgit Puschner
Journal:  Toxins (Basel)       Date:  2014-06-10       Impact factor: 4.546

10.  Comparison of Protein Phosphatase Inhibition Assay with LC-MS/MS for Diagnosis of Microcystin Toxicosis in Veterinary Cases.

Authors:  Caroline E Moore; Jeanette Juan; Yanping Lin; Cynthia L Gaskill; Birgit Puschner
Journal:  Mar Drugs       Date:  2016-03-09       Impact factor: 5.118
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