Literature DB >> 16618592

Multiple paths to multispecificity.

Roy A Mariuzza1.   

Abstract

The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

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Substances：

Year:  2006        PMID： 16618592     DOI： 10.1016/j.immuni.2006.03.009

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  19 in total

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2.  Exploring antibody recognition of sequence space through random-sequence peptide microarrays.

Authors:  Rebecca F Halperin; Phillip Stafford; Stephen Albert Johnston
Journal:  Mol Cell Proteomics       Date:  2010-11-09       Impact factor: 5.911

3.  Evolving concepts of specificity in immune reactions.

Authors:  Herman N Eisen; Arup K Chakraborty
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Review 4.  Protein promiscuity and its implications for biotechnology.

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5.  Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR.

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

6.  Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.

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Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-16       Impact factor: 11.205

Review 7.  A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2013-12-14       Impact factor: 9.261

8.  Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.

Authors:  Jonathan K Fleming; Jonathan M Wojciak; Mary-Ann Campbell; Tom Huxford
Journal:  J Mol Biol       Date:  2011-03-15       Impact factor: 5.469

9.  Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility.

Authors:  Mariana Babor; Tanja Kortemme
Journal:  Proteins       Date:  2009-06

10.  Correcting the record of structural publications requires joint effort of the community and journal editors.

Authors:  Bernhard Rupp; Alexander Wlodawer; Wladek Minor; John R Helliwell; Mariusz Jaskolski
Journal:  FEBS J       Date:  2016-06-10       Impact factor: 5.542
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