| Literature DB >> 27229767 |
Bernhard Rupp1,2, Alexander Wlodawer3, Wladek Minor4, John R Helliwell5, Mariusz Jaskolski6.
Abstract
Seriously flawed and even fictional models of biomolecular crystal structures, although rare, still persist in the record of structural repositories and databases. The ensuing problems of database contamination and persistence of publications based on incorrect structure models must be effectively addressed. The burden cannot be simply left to the critical voices who take the effort to contribute dissenting comments that are mostly ignored. The entire structural biology community, and particularly the journal editors who exercise significant power in this respect, must engage in a constructive dialog lest structural biology lose its credibility as an evidence-based empirical science.Entities:
Keywords: X-ray crystal structure models; biomolecular crystallography; database integrity; error correction; structural databases
Mesh:
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Year: 2016 PMID: 27229767 PMCID: PMC5124416 DOI: 10.1111/febs.13765
Source DB: PubMed Journal: FEBS J ISSN: 1742-464X Impact factor: 5.542