Literature DB >> 16458509

Synthesis and anticancer activity of thiosemicarbazones.

Wei-xiao Hu1, Wei Zhou, Chun-nian Xia, Xi Wen.   

Abstract

Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.

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Year:  2006        PMID： 16458509     DOI： 10.1016/j.bmcl.2006.01.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  25 in total

1.  Trypanocidal and cytotoxic evaluation of synthesized thiosemicarbazones as potential drug leads against sleeping sickness.

Authors:  Bienvenu Glinma; Sika D S Kpoviessi; Fernand A Gbaguidi; Coco N Kapanda; Joanne Bero; Joëlle Quetin-Leclercq; Mansourou Moudachirou; Jacques Poupaert; Georges C Accrombessi; Emma W Gachomo; Lamine Baba-Moussa; Simeon O Kotchoni
Journal:  Mol Biol Rep       Date:  2014-01-10       Impact factor: 2.316

2.  DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes: synthesis, spectroscopy, electrochemistry, and X-ray crystallography.

Authors:  R Prabhakaran; P Kalaivani; R Huang; P Poornima; V Vijaya Padma; F Dallemer; K Natarajan
Journal:  J Biol Inorg Chem       Date:  2012-12-29       Impact factor: 3.358

3.  Di-n-but-yl[N'-(3-meth-oxy-2-oxidobenzyl-idene)-N-phenyl-carbamohydrazono-thio-ato]tin(IV): crystal structure, Hirshfeld surface analysis and computational study.

Authors:  Enis Nadia Md Yusof; Huey Chong Kwong; Thiruventhan Karunakaran; Thahira B S A Ravoof; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-02-23

4.  A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA-125a-5p and miRNA-181a-5p.

Authors:  Rania El Majzoub; Mohammad Fayyad-Kazan; Assaad Nasr El Dine; Rawan Makki; Eva Hamade; René Grée; Ali Hachem; Rabih Talhouk; Hussein Fayyad-Kazan; Bassam Badran
Journal:  Genes Genomics       Date:  2019-09-20       Impact factor: 1.839

5.  Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.

Authors:  Haiyuan Zhang; Ronald Thomas; David Oupicky; Fangyu Peng
Journal:  J Biol Inorg Chem       Date:  2007-10-02       Impact factor: 3.358

6.  1-Benzyl-idene-amino-3-(4-methyl-phen-yl)thio-urea.

Authors:  Yan-Ling Zhang; Zhi-Hong Xu; Fu-Juan Zhang; Feng-Ling Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-22

7.  Ethyl 3-[2-(p-tolyl-carbamothio-yl)hydrazinyl-idene]butano-ate.

Authors:  Yan-Ling Zhang; Xu-Feng Hou; Fu-Juan Zhang; Feng-Ling Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-30

8.  3-[(Furan-2-yl-methyl-idene)amino]-1-(4-methyl-phen-yl)thio-urea.

Authors:  Yan-Ling Zhang; Fu-Juan Zhang; Zhi-Hong Xu; Feng-Ling Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-08

9.  Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl].

Authors:  Shadia A Elsayed; Ahmed M El-Hendawy; Sahar I Mostafa; Bertrand J Jean-Claude; Margarita Todorova; Ian S Butler
Journal:  Bioinorg Chem Appl       Date:  2010-07-01       Impact factor: 7.778

10.  3-[(Cyclo-hexyl-idene)amino]-1-(4-methyl-phen-yl)thio-urea.

Authors:  Yan-Ling Zhang; Xiao-Wei Zhang; Fu-Juan Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-04-29
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