Literature DB >> 17909866

Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.

Haiyuan Zhang1, Ronald Thomas, David Oupicky, Fangyu Peng.   

Abstract

Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.

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Year:  2007        PMID： 17909866     DOI： 10.1007/s00775-007-0299-6

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  31 in total

1.  Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase.

Authors:  G Rappa; A Lorico; M C Liu; G D Kruh; A H Cory; J G Cory; A C Sartorelli
Journal:  Biochem Pharmacol       Date:  1997-09-15       Impact factor: 5.858

2.  The cytotoxicity of copper(II) complexes of 2-acetyl-pyridyl-4N-substituted thiosemicarbazones.

Authors:  M C Miller; C N Stineman; J R Vance; D X West; I H Hall
Journal:  Anticancer Res       Date:  1998 Nov-Dec       Impact factor: 2.480

3.  Copper(II) complexes with substituted thiosemicarbazones of alpha-ketoglutaric acid: synthesis, X-ray structures, DNA binding studies, and nuclease and biological activity.

Authors:  Monica Baldini; Marisa Belicchi-Ferrari; Franco Bisceglie; Pier Paolo Dall'aglio; Giorgio Pelosi; Silvana Pinelli; Pieralberto Tarasconi
Journal:  Inorg Chem       Date:  2004-11-01       Impact factor: 5.165

Review 4.  Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis.

Authors:  Di Chen; Fangyu Peng; Qiuzhi Cindy Cui; Kenyon G Daniel; Shirley Orlu; Jianguo Liu; Q Ping Dou
Journal:  Front Biosci       Date:  2005-09-01

5.  New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.

Authors:  Antonios Kolocouris; Kostas Dimas; Christophe Pannecouque; Myriam Witvrouw; George B Foscolos; George Stamatiou; George Fytas; Grigoris Zoidis; Nicolas Kolocouris; Graciela Andrei; Robert Snoeck; Erik De Clercq
Journal:  Bioorg Med Chem Lett       Date:  2002-03-11       Impact factor: 2.823

Review 6.  Mechanisms of p53-induced apoptosis.

Authors:  M R Bennett
Journal:  Biochem Pharmacol       Date:  1999-10-01       Impact factor: 5.858

7.  Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.

Authors:  J G Cory; A H Cory; G Rappa; A Lorico; M C Liu; T S Lin; A C Sartorelli
Journal:  Biochem Pharmacol       Date:  1994-07-19       Impact factor: 5.858

8.  Cu(II) complexes with heterocyclic substituted thiosemicarbazones: the case of 5-formyluracil. Synthesis, characterization, x-ray structures, DNA interaction studies, and biological activity.

Authors:  Monica Baldini; Marisa Belicchi-Ferrari; Franco Bisceglie; Giorgio Pelosi; Silvana Pinelli; Pieralberto Tarasconi
Journal:  Inorg Chem       Date:  2003-03-24       Impact factor: 5.165

9.  Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone-transition metal complexes.

Authors:  W C Kaska; C Carrano; J Michalowski; J Jackson; W Levinson
Journal:  Bioinorg Chem       Date:  1978

10.  Comparative cytotoxic and biochemical effects of ligands and metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones.

Authors:  L A Saryan; E Ankel; C Krishnamurti; D H Petering; H Elford
Journal:  J Med Chem       Date:  1979-10       Impact factor: 7.446
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  17 in total

1.  Turning tumor-promoting copper into an anti-cancer weapon via high-throughput chemistry.

Authors:  F Wang; P Jiao; M Qi; M Frezza; Q P Dou; B Yan
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

2.  A Study on Spectro-Analytical Aspects, DNA - Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 - (1 - (6 - methoxybenzo [d] thiazol - 2 - ylimino) ethyl) - 6 - methyl - 3H - pyran - 2, 4 - dione and its Metal Complexes.

Authors:  Mudavath Ravi; Kishan Prasad Chennam; B Ushaiah; Ravi Kumar Eslavath; Shyam Perugu; Rajanna Ajumeera; Ch Sarala Devi
Journal:  J Fluoresc       Date:  2015-08-28       Impact factor: 2.217

3.  Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies.

Authors:  Büşra Kaya; Zehra Kübra Yılmaz; Onur Şahin; Belma Aslim; Ümmügülsüm Tükenmez; Bahri Ülküseven
Journal:  J Biol Inorg Chem       Date:  2019-03-20       Impact factor: 3.358

4.  Novel pyridinecarboxaldehyde thiosemicarbazone conjugated magnetite nanoparticulates (MNPs) promote apoptosis in human lung cancer A549 cells.

Authors:  Alireza Habibi; Seyed Ataollah Sadat Shandiz; Ali Salehzadeh; Zeinab Moradi-Shoeili
Journal:  J Biol Inorg Chem       Date:  2019-10-19       Impact factor: 3.358

5.  Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands.

Authors:  Nerissa A Lewis; Fange Liu; Luke Seymour; Anthony Magnusen; Travis R Erves; Jessa Faye Arca; Floyd A Beckford; Ramaiyer Venkatraman; Antonio González-Sarrías; Frank R Fronczek; Don G Vanderveer; Navindra P Seeram; Aimin Liu; William L Jarrett; Alvin A Holder
Journal:  Eur J Inorg Chem       Date:  2012-02-01       Impact factor: 2.524

6.  Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde-Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging.

Authors:  Fang Xie; Fangyu Peng
Journal:  J Fluoresc       Date:  2017-06-26       Impact factor: 2.217

7.  A New Thiosemicarbazone-Based Fluorescence "Turn-on" Sensor for Zn(2+) Recognition with a Large Stokes Shift and its Application in Live Cell Imaging.

Authors:  Lijun Tang; Zhenlong Huang; Zhuxuan Zheng; Keli Zhong; Yanjiang Bian
Journal:  J Fluoresc       Date:  2016-06-22       Impact factor: 2.217

8.  Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging.

Authors:  Fang Xie; Huawei Cai; Fangyu Peng
Journal:  J Biol Inorg Chem       Date:  2018-07-13       Impact factor: 3.358

9.  Anticancer Activity of Copper Complex of (4R)-(-)-2-Thioxo-4-thiazolidinecarboxylic Acid and 3-Rhodaninepropionic Acid on Prostate and Breast Cancer Cells by Fluorescent Microscopic Imaging.

Authors:  Fang Xie; Fangyu Peng
Journal:  J Fluoresc       Date:  2017-09-09       Impact factor: 2.217

10.  Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)-benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cells.

Authors:  Marta González-Alvarez; Gloria Alzuet; Joaquín Borrás; Lucas del Castillo-Agudo; Jose Manuel Montejo-Bernardo; Angel Gutiérrez-Rodríguez; Santiago García-Granda
Journal:  J Biol Inorg Chem       Date:  2008-07-24       Impact factor: 3.358
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