Literature DB >> 16389544

Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Igor A Parshikov1, Brushapathy Miriyala, Kannoth M Muraleedharan, Mitchell A Avery, John S Williamson.   

Abstract

Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. 5Beta-hydroxyartemisinin and 7beta-hydroxyartemisinin were isolated in 63 and 32% yields, respectively, from the extract of E. amstelodami, and 80 and 19%, respectively, from the extract of A. niger.

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Year:  2005        PMID： 16389544     DOI： 10.1007/s10295-005-0071-2

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  8 in total

Review 1.  A medicinal chemistry perspective on artemisinin and related endoperoxides.

Authors:  Paul M O'Neill; Gary H Posner
Journal:  J Med Chem       Date:  2004-06-03       Impact factor: 7.446

2.  Biotransformation of N-acetylphenothiazine by fungi.

Authors:  I A Parshikov; J P Freeman; A J Williams; J D Moody; J B Sutherland
Journal:  Appl Microbiol Biotechnol       Date:  1999-10       Impact factor: 4.813

3.  C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.

Authors:  S Ekthawatchai; S Kamchonwongpaisan; P Kongsaeree; B Tarnchompoo; Y Thebtaranonth; Y Yuthavong
Journal:  J Med Chem       Date:  2001-12-20       Impact factor: 7.446

Review 4.  Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Authors:  Kristina Borstnik; Ik-hyeon Paik; Theresa A Shapiro; Gary H Posner
Journal:  Int J Parasitol       Date:  2002-12-04       Impact factor: 3.981

5.  Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegans.

Authors:  Igor A Parshikov; Kannoth M Muraleedharan; Bruhaspathy Miriyala; Mitchell A Avery; John S Williamson
Journal:  J Nat Prod       Date:  2004-09       Impact factor: 4.050

6.  Transformation of artemisinin by Cunninghamella elegans.

Authors:  I A Parshikov; K M Muraleedharan; M A Avery; J S Williamson
Journal:  Appl Microbiol Biotechnol       Date:  2004-01-21       Impact factor: 4.813

7.  Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.

Authors:  Ji-Xun Zhan; Yuan-Xing Zhang; Hong-Zhu Guo; Jian Han; Li-Li Ning; De-An Guo
Journal:  J Nat Prod       Date:  2002-11       Impact factor: 4.050

8.  Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.

Authors:  Mitchell A Avery; Kannoth M Muraleedharan; Prashant V Desai; Achintya K Bandyopadhyaya; Marise M Furtado; Babu L Tekwani
Journal:  J Med Chem       Date:  2003-09-25       Impact factor: 7.446
  8 in total
  6 in total

1.  Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus.

Authors:  Bruno Alves Rocha; Mônica Tallarico Pupo; Gilmara Ausech Antonucci; Suely Vilela Sampaio; Raquel de Melo Alves Paiva; Suraia Said; Leonardo Gobbo-Neto; Fernando Batista Da Costa
Journal:  J Ind Microbiol Biotechnol       Date:  2012-07-11       Impact factor: 3.346

2.  7β-Hydroxy-artemisinin.

Authors:  Paulo B Carvalho; Bo Liu; Yunshan Wu; John S Williamson; Mitchell A Avery
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-09

3.  Microbial transformation of artemisinin by Aspergillus terreus.

Authors:  Hongchang Yu; Baowu Zhu; Yulian Zhan
Journal:  Bioresour Bioprocess       Date:  2017-07-17

4.  Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger.

Authors:  Jiaer Luo; Rebecca Mobley; Sian Woodfine; Falko Drijfhout; Paul Horrocks; Xiao-Dong Ren; Wen-Wu Li
Journal:  Appl Microbiol Biotechnol       Date:  2022-03-31       Impact factor: 4.813

5.  Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity.

Authors:  Kaidong Zhang; Brian M Shafer; Matthew D Demars; Harry A Stern; Rudi Fasan
Journal:  J Am Chem Soc       Date:  2012-11-02       Impact factor: 15.419

6.  Taxonomic Characterization and Secondary Metabolite Profiling of Aspergillus Section Aspergillus Contaminating Feeds and Feedstuffs.

Authors:  Mariana Greco; Minna Kemppainen; Graciela Pose; Alejandro Pardo
Journal:  Toxins (Basel)       Date:  2015-09-02       Impact factor: 4.546
  6 in total

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