Literature DB >> 12444705

Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.

Ji-Xun Zhan1, Yuan-Xing Zhang, Hong-Zhu Guo, Jian Han, Li-Li Ning, De-An Guo.   

Abstract

Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.

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Year:  2002        PMID： 12444705     DOI： 10.1021/np020113r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus.

Authors:  Bruno Alves Rocha; Mônica Tallarico Pupo; Gilmara Ausech Antonucci; Suely Vilela Sampaio; Raquel de Melo Alves Paiva; Suraia Said; Leonardo Gobbo-Neto; Fernando Batista Da Costa
Journal:  J Ind Microbiol Biotechnol       Date:  2012-07-11       Impact factor: 3.346

2.  Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Authors:  Igor A Parshikov; Brushapathy Miriyala; Kannoth M Muraleedharan; Mitchell A Avery; John S Williamson
Journal:  J Ind Microbiol Biotechnol       Date:  2005-12-31       Impact factor: 3.346

3.  7β-Hydroxy-artemisinin.

Authors:  Paulo B Carvalho; Bo Liu; Yunshan Wu; John S Williamson; Mitchell A Avery
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-09

4.  Microbial transformation of artemisinin by Aspergillus terreus.

Authors:  Hongchang Yu; Baowu Zhu; Yulian Zhan
Journal:  Bioresour Bioprocess       Date:  2017-07-17

Review 5.  Late-Stage Diversification of Natural Products.

Authors:  Benke Hong; Tuoping Luo; Xiaoguang Lei
Journal:  ACS Cent Sci       Date:  2020-04-22       Impact factor: 14.553

6.  Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger.

Authors:  Jiaer Luo; Rebecca Mobley; Sian Woodfine; Falko Drijfhout; Paul Horrocks; Xiao-Dong Ren; Wen-Wu Li
Journal:  Appl Microbiol Biotechnol       Date:  2022-03-31       Impact factor: 4.813

7.  Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity.

Authors:  Kaidong Zhang; Brian M Shafer; Matthew D Demars; Harry A Stern; Rudi Fasan
Journal:  J Am Chem Soc       Date:  2012-11-02       Impact factor: 15.419
  7 in total

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