Literature DB >> 11741486

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.

S Ekthawatchai1, S Kamchonwongpaisan, P Kongsaeree, B Tarnchompoo, Y Thebtaranonth, Y Yuthavong.   

Abstract

Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grignard reagents to artemisitene provided C-16-derived artemisinin monomers, dimers, trimers, and tetramers whose antimalarial and cytotoxic activities have been evaluated.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11741486     DOI： 10.1021/jm0103007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Dinitroaliphatics as linkers: application in the synthesis of novel artemisinin carba-dimer.

Authors:  Abhishek Goswami; Partha Pratim Saikia; Bishwajit Saikia; Nabin C Barua
Journal:  Mol Divers       Date:  2011-01-04       Impact factor: 2.943

2.  Potent antiviral activity of topoisomerase I and II inhibitors against Kaposi's sarcoma-associated herpesvirus.

Authors:  Lorenzo González-Molleda; Yan Wang; Yan Yuan
Journal:  Antimicrob Agents Chemother       Date:  2011-11-21       Impact factor: 5.191

3.  Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

Authors:  Igor A Parshikov; Brushapathy Miriyala; Kannoth M Muraleedharan; Mitchell A Avery; John S Williamson
Journal:  J Ind Microbiol Biotechnol       Date:  2005-12-31       Impact factor: 3.346

4.  Glycyrrhiza glabra (Linn.) and Lavandula officinalis (L.) cell suspension cultures-based biotransformation of β-artemether.

Authors:  Suman Patel; Rashmi Gaur; Mohita Upadhyaya; Archana Mathur; Ajay K Mathur; Rajendra S Bhakuni
Journal:  J Nat Med       Date:  2011-05-05       Impact factor: 2.343

5.  Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Authors:  Andrew S Rosenthal; Xiaochun Chen; Jun O Liu; Diana C West; Paul J Hergenrother; Theresa A Shapiro; Gary H Posner
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

6.  Optical Properties of Artemisinin and Its Derivatives.

Authors:  Jialin Ma; Wenhua Qiao; Xijiao Mu; Jun Dong; Jun Quan; Chunhua Tian
Journal:  ACS Omega       Date:  2020-11-23
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.