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Literature DB >> 16309305

Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.

Omar E Christian¹, Jennifer Compton, Keisha R Christian, Susan L Mooberry, Fredrick A Valeriote, Phillip Crews.

Abstract

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

Entities: Chemical Disease Species

Mesh：

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Year: 2005 PMID： 16309305 PMCID： PMC3972004 DOI： 10.1021/np050293f

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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