| Literature DB >> 2199089 |
T Hirose1, Y Izawa, K Koyama, S Natori, K Iida, I Yahara, S Shimaoka, K Maruyama.
Abstract
The effects of ten 10-phenyl-[11]cytochalasins produced by Phomopsis sp. including novel compounds having 5,7- or 6,7-glycol structures and their derivatives, on the cell morphology and actin distribution in C3H-2K cells, as well as on lymphocyte capping and actin polymerization, were examined. The structure-activity relationship reported in the previous papers has been confirmed. The novel glycol type compounds showed little or no activity, suggesting the importance of the perhydroisoindol-1-one nucleus for the manifestation of the cytochalasin actions.Entities:
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Year: 1990 PMID： 2199089 DOI： 10.1248/cpb.38.971
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645