Literature DB >> 15568779

Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.

Yoshiharu Okuno1, Mitsuo Miyazawa.   

Abstract

Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.

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Year:  2004        PMID： 15568779     DOI： 10.1021/np034007g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: Influence of formulation parameters on Polymethoxyflavone crystallization.

Authors:  Yan Li; Jinkai Zheng; Hang Xiao; David Julian McClements
Journal:  Food Hydrocoll       Date:  2011-09-17       Impact factor: 9.147

2.  Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.

Authors:  Omar E Christian; Jennifer Compton; Keisha R Christian; Susan L Mooberry; Fredrick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2005-11       Impact factor: 4.050

3.  Functional analysis of unfermented and fermented citrus peels and physical properties of citrus peel-added doughs for bread making.

Authors:  Yung-Shin Shyu; Tzu-Chi Lu; Chuan-Chuan Lin
Journal:  J Food Sci Technol       Date:  2013-02-09       Impact factor: 2.701

Review 4.  Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents.

Authors:  Takahiro Matsumoto; Tetsushi Watanabe
Journal:  Genes Environ       Date:  2020-04-16

5.  Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.

Authors:  Ichiro Kawahata; Tatsuya Suzuki; Evelyn Gutiérrez Rico; Shuichi Kusano; Hiroshi Tamura; Yoshihiro Mimaki; Tohru Yamakuni
Journal:  J Nat Med       Date:  2017-05-09       Impact factor: 2.343

Review 6.  Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents.

Authors:  Takahiro Matsumoto; Tetsushi Watanabe
Journal:  Genes Environ       Date:  2020-04-16
  6 in total

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