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Literature DB >> 21174394

Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp.

Hélène C Vervoort¹, Marija Drašković, Phillip Crews.

Abstract

The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) was used to turn on the biosynthesis of EGM-556, a new cyclodepsipeptide of hybrid biosynthetic origin, isolated from the Floridian marine sediment-derived fungus Microascus sp. The absolute configurations of three chiral centers were determined by Marfey's derivatization. EGM-556 represents one of the few examples in which silent biosynthetic genes, encoding a new secondary metabolite, were activated by means of epigenetic manipulation of the fungal metabolome.

Entities: Chemical Species

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Year: 2010 PMID： 21174394 PMCID： PMC3031758 DOI： 10.1021/ol1027199

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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