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Literature DB >> 16274996

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.

L Bouissane¹, S El Kazzouli, S Léonce, B Pfeiffer, E M Rakib, M Khouili, G Guillaumet.

Abstract

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC(50) of 0.44 microM.

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Year: 2005 PMID： 16274996 DOI： 10.1016/j.bmc.2005.09.037

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

27 in total

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Journal: Monatsh Chem Date: 2012-05-15 Impact factor: 1.451

2. Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence.

Authors: James M Salovich; Craig W Lindsley; Corey R Hopkins
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3. Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.

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Journal: Invest New Drugs Date: 2018-07-18 Impact factor: 3.850

4. Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity.

Authors: Corina Cheptea; Valeriu Sunel; Ana Cezarina Morosanu; Dan Gheorghe Dimitriu; Mihaela Maria Dulcescu-Oprea; Mihai-Daniel Angheluta; Mihaela Miron; Cristina Delia Nechifor; Dana Ortansa Dorohoi; Razvan Nicolae Malancus
Journal: Biomedicines Date: 2021-04-26

5. Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity.

Authors: Gabriel E Büchel; Iryna N Stepanenko; Michaela Hejl; Michael A Jakupec; Bernhard K Keppler; Petra Heffeter; Walter Berger; Vladimir B Arion
Journal: J Inorg Biochem Date: 2012-04-10 Impact factor: 4.155

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.

1. Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides.

2. Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence.

3. Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.

4. Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity.

5. Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity.

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7. 1-Allyl-6-nitro-1H-indazole.

8. Ethyl 3-[6-(4-meth-oxy-benzene-sulfon-amido)-2H-indazol-2-yl]propano-ate monohydrate.

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10. 1-(4-Methyl-phenyl-sulfon-yl)-5,6-di-nitro-1H-indazole.