Literature DB >> 26166869

Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides.

Katarzyna Gobis1, Henryk Foks1, Katarzyna Wiśniewska2, Maria Dąbrowska-Szponar2, Ewa Augustynowicz-Kopeć3, Agnieszka Napiórkowska3, Artur Sikorski4.   

Abstract

ABSTRACT: A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the α position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal. GRAPHICAL ABSTRACT: .

Entities:  

Keywords:  Antimicrobial activity; Crystal structure; Heterocycles; Structure–activity relationship; Sulfonamidine; Synthesis

Year:  2012        PMID： 26166869      PMCID： PMC4494770          DOI： 10.1007/s00706-012-0769-6

Source DB:  PubMed          Journal:  Monatsh Chem        ISSN： 0026-9247            Impact factor:   1.451


  24 in total

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8.  Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

Authors:  Alexander Weber; Angela Casini; Andreas Heine; Daniel Kuhn; Claudiu T Supuran; Andrea Scozzafava; Gerhard Klebe
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  2 in total

1.  Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides.

Authors:  Katarzyna Gobis; Henryk Foks; Jarosław Sławiński; Artur Sikorski; Damian Trzybiński; Ewa Augustynowicz-Kopeć; Agnieszka Napiórkowska; Krzysztof Bojanowski
Journal:  Monatsh Chem       Date:  2013-01-25       Impact factor: 1.451

2.  Synthesis and biological activity of novel 3-heteroaryl-2H-pyrido[4,3-e][1,2,4]thiadiazine and 3-heteroaryl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxides.

Authors:  Katarzyna Gobis; Henryk Foks; Jarosłw Sławiński; Ewa Augustynowicz-Kopeć; Agnieszka Napiórkowska
Journal:  Monatsh Chem       Date:  2013-05-14       Impact factor: 1.451
  2 in total

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