PURPOSE: Assess the effect of heart rate on diagnostic accuracy for the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). MATERIAL AND METHODS: About 120 patients (105 males; 59+/-11 years) with suspected coronary artery disease who underwent conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA (Sensation 16, Siemens, Germany), with the following protocol: collimation 16 x 0.75 mm, gantry rotation time 420 ms, feed/rotation 3.0 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol (Visipaque 320 mg l/ml, Amersham, UK) at 4 ml/s and the delay was defined with a bolus tracking technique. In all patients the mean heart rate (HR) during the scan was used as a criteria to divide the population in two groups of 60 patients each. In one group (Low HR) the 60 patients with lower heart rates, and in the other group (High HR) the patients with higher heart rates. In the two groups diagnostic accuracy (per coronary segment) for the detection of significant stenosis (>or=50% lumen reduction) was evaluated in vessels >or=2 mm of diameter using quantitative CA as reference standard. The difference in diagnostic accuracy were compared with a Chi(2) test and a p<0.05 was considered significant. RESULTS: There was no significant difference between the two groups regarding age, gender, weight, mean intravascular attenuation, and calcium score. Overall 1,310 (652 for Low HR and 658 for High HR) segments with 219 (105 for Low HR and 114 for High HR) significant lesions were available for the analysis. The average heart rate was 52+/-4 HU and 63+/-5 HU for Low HR and High HR, respectively (p<0.001). The sensitivity and specificity were 92 and 96% for Low HR and 90 and 92% for High HR (p<0.05). There were 22 vs. 44 false positives, and 8 vs. 12 false negatives in the Low HR and High HR, respectively. CONCLUSION: Increasing HR significantly deteriorates diagnostic accuracy in MSCT-CA.
PURPOSE: Assess the effect of heart rate on diagnostic accuracy for the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). MATERIAL AND METHODS: About 120 patients (105 males; 59+/-11 years) with suspected coronary artery disease who underwent conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA (Sensation 16, Siemens, Germany), with the following protocol: collimation 16 x 0.75 mm, gantry rotation time 420 ms, feed/rotation 3.0 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol (Visipaque 320 mg l/ml, Amersham, UK) at 4 ml/s and the delay was defined with a bolus tracking technique. In all patients the mean heart rate (HR) during the scan was used as a criteria to divide the population in two groups of 60 patients each. In one group (Low HR) the 60 patients with lower heart rates, and in the other group (High HR) the patients with higher heart rates. In the two groups diagnostic accuracy (per coronary segment) for the detection of significant stenosis (>or=50% lumen reduction) was evaluated in vessels >or=2 mm of diameter using quantitative CA as reference standard. The difference in diagnostic accuracy were compared with a Chi(2) test and a p<0.05 was considered significant. RESULTS: There was no significant difference between the two groups regarding age, gender, weight, mean intravascular attenuation, and calcium score. Overall 1,310 (652 for Low HR and 658 for High HR) segments with 219 (105 for Low HR and 114 for High HR) significant lesions were available for the analysis. The average heart rate was 52+/-4 HU and 63+/-5 HU for Low HR and High HR, respectively (p<0.001). The sensitivity and specificity were 92 and 96% for Low HR and 90 and 92% for High HR (p<0.05). There were 22 vs. 44 false positives, and 8 vs. 12 false negatives in the Low HR and High HR, respectively. CONCLUSION: Increasing HR significantly deteriorates diagnostic accuracy in MSCT-CA.
Authors: W G Austen; J E Edwards; R L Frye; G G Gensini; V L Gott; L S Griffith; D C McGoon; M L Murphy; B B Roe Journal: Circulation Date: 1975-04 Impact factor: 29.690
Authors: K Nieman; B J Rensing; R-J M van Geuns; J Vos; P M T Pattynama; G P Krestin; P W Serruys; P J de Feyter Journal: Heart Date: 2002-11 Impact factor: 5.994
Authors: Koen Nieman; Filippo Cademartiri; Pedro A Lemos; Rolf Raaijmakers; Peter M T Pattynama; Pim J de Feyter Journal: Circulation Date: 2002-10-15 Impact factor: 29.690
Authors: Stephen Schroeder; Andreas F Kopp; Axel Kuettner; Christof Burgstahler; Christian Herdeg; Martin Heuschmid; Andreas Baumbach; Claus D Claussen; Karl R Karsch; Ludger Seipel Journal: Clin Imaging Date: 2002 Mar-Apr Impact factor: 1.605
Authors: Dieter Ropers; Ulrich Baum; Karsten Pohle; Katharina Anders; Stefan Ulzheimer; Bernd Ohnesorge; Christian Schlundt; Werner Bautz; Werner G Daniel; Stephan Achenbach Journal: Circulation Date: 2003-02-11 Impact factor: 29.690
Authors: Nico R Mollet; Filippo Cademartiri; Koen Nieman; Francesco Saia; Pedro A Lemos; Eugene P McFadden; Peter M T Pattynama; Patrick W Serruys; Gabriel P Krestin; Pim J de Feyter Journal: J Am Coll Cardiol Date: 2004-06-16 Impact factor: 24.094
Authors: Maureen M Henneman; Jeroen J Bax; Joanne D Schuijf; Ernst E van der Wall Journal: Int J Cardiovasc Imaging Date: 2005-12-10 Impact factor: 2.357
Authors: Sebastian Leschka; Lars Husmann; Lotus M Desbiolles; Oliver Gaemperli; Tiziano Schepis; Pascal Koepfli; Thomas Boehm; Borut Marincek; Philipp A Kaufmann; Hatem Alkadhi Journal: Eur Radiol Date: 2006-05-13 Impact factor: 5.315
Authors: Taylor Richards; Gregory M Sturgeon; Juan Carlos Ramirez-Giraldo; Geoffrey D Rubin; Lynne Hurwitz Koweek; William Paul Segars; Ehsan Samei Journal: J Med Imaging (Bellingham) Date: 2018-01-17
Authors: Gastón A Rodriguez-Granillo; Miguel A Rosales; Elina Degrossi; Inés Durbano; Alfredo E Rodriguez Journal: Int J Cardiovasc Imaging Date: 2006-07-05 Impact factor: 2.357
Authors: Marc Dewey; Andrea L Vavere; Armin Arbab-Zadeh; Julie M Miller; Leonardo Sara; Christopher Cox; Ilan Gottlieb; Kunihiro Yoshioka; Narinder Paul; John Hoe; Albert de Roos; Albert C Lardo; Joao A Lima; Melvin E Clouse Journal: AJR Am J Roentgenol Date: 2010-01 Impact factor: 3.959
Authors: H Brodoefel; A Reimann; M Heuschmid; A Küttner; T Beck; C Burgstahler; C D Claussen; S Schroeder; A F Kopp Journal: Eur Radiol Date: 2006-02-24 Impact factor: 5.315