BACKGROUND: We analyzed the accuracy of multi-detector row spiral computed tomography (MDCT) using a 16-slice CT scanner with improved spatial and temporal resolution, as well as routine premedication with beta-blockers for detection of coronary stenoses. METHODS AND RESULTS: Seventy-seven patients with suspected coronary disease were studied by MDCT (12x0.75-mm cross-sections, 420 ms rotation, 100 mL contrast agent IV at 5 mL/s). Patients with a heart rate above 60/min received 50 mg atenolol before the scan. In axial MDCT images and multiplanar reconstructions, all coronary arteries and side branches with a diameter of 1.5 mm or more were assessed for the presence of stenoses exceeding 50% diameter reduction. In comparison to invasive coronary angiography, MDCT correctly classified 35 of 41 patients (85%) as having at least 1 coronary stenosis and correctly detected 57 of 78 coronary lesions (73%). After excluding 38 of 308 coronary arteries (left main, left anterior descending, left circumflex, and right coronary artery in 77 patients) classified as unevaluable by MDCT (12%), 57 of 62 lesions were detected, and absence of stenosis was correctly identified in 194 of 208 arteries (sensitivity: 92%; specificity: 93%; accuracy: 93%; positive and negative predictive values: 79% and 97%). CONCLUSIONS: MDCT coronary angiography with improved spatial resolution and premedication with oral beta-blockade permits detection of coronary artery stenoses with high accuracy and a low rate of unevaluable arteries.
BACKGROUND: We analyzed the accuracy of multi-detector row spiral computed tomography (MDCT) using a 16-slice CT scanner with improved spatial and temporal resolution, as well as routine premedication with beta-blockers for detection of coronary stenoses. METHODS AND RESULTS: Seventy-seven patients with suspected coronary disease were studied by MDCT (12x0.75-mm cross-sections, 420 ms rotation, 100 mL contrast agent IV at 5 mL/s). Patients with a heart rate above 60/min received 50 mg atenolol before the scan. In axial MDCT images and multiplanar reconstructions, all coronary arteries and side branches with a diameter of 1.5 mm or more were assessed for the presence of stenoses exceeding 50% diameter reduction. In comparison to invasive coronary angiography, MDCT correctly classified 35 of 41 patients (85%) as having at least 1 coronary stenosis and correctly detected 57 of 78 coronary lesions (73%). After excluding 38 of 308 coronary arteries (left main, left anterior descending, left circumflex, and right coronary artery in 77 patients) classified as unevaluable by MDCT (12%), 57 of 62 lesions were detected, and absence of stenosis was correctly identified in 194 of 208 arteries (sensitivity: 92%; specificity: 93%; accuracy: 93%; positive and negative predictive values: 79% and 97%). CONCLUSIONS: MDCT coronary angiography with improved spatial resolution and premedication with oral beta-blockade permits detection of coronary artery stenoses with high accuracy and a low rate of unevaluable arteries.
Authors: Hae Chang Jeong; Youngkeun Ahn; Jum Suk Ko; Min Goo Lee; Doo Sun Sim; Keun Ho Park; Nam Sik Yoon; Hyun Ju Youn; Young Joon Hong; Kye Hun Kim; Hyung Wook Park; Ju Han Kim; Yun-Hyeon Kim; Myung Ho Jeong; Jeong Gwan Cho; Jong Chun Park; Jung Chaee Kang Journal: Int J Cardiovasc Imaging Date: 2010-10-05 Impact factor: 2.357
Authors: Filippo Cademartiri; Nico Mollet; Aad van der Lugt; Koen Nieman; Peter M T Pattynama; Pim J de Feyter; Gabriel P Krestin Journal: Eur Radiol Date: 2003-12-19 Impact factor: 5.315
Authors: Ulrich Baum; Katharina Anders; Dieter Ropers; Anton Noemayr; Axel Schmid; Theresa Seeliger; Helmut Singer; Werner G Daniel; Werner Bautz; Stephan Achenbach Journal: Eur Radiol Date: 2004-04-09 Impact factor: 5.315
Authors: B J Wintersperger; G Bastarrika; K Nikolaou; C Rist; A Huber; A Knez; M F Reiser; C R Becker; C Vicol Journal: Radiologe Date: 2004-02 Impact factor: 0.635