Literature DB >> 15931375

Factors affecting statistical power in the detection of genetic association.

Derek Gordon1, Stephen J Finch.   

Abstract

The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.

Mesh：

Substances：

Year:  2005        PMID： 15931375      PMCID： PMC1137002          DOI： 10.1172/JCI24756

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  110 in total

1.  A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data.

Authors:  J A Douglas; M Boehnke; K Lange
Journal:  Am J Hum Genet       Date:  2000-03-28       Impact factor: 11.025

2.  Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.

Authors:  H H Göring; J D Terwilliger
Journal:  Am J Hum Genet       Date:  2000-03-23       Impact factor: 11.025

3.  Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters.

Authors:  H H Göring; J D Terwilliger
Journal:  Am J Hum Genet       Date:  2000-03-23       Impact factor: 11.025

4.  Genomic control for association studies.

Authors:  B Devlin; K Roeder
Journal:  Biometrics       Date:  1999-12       Impact factor: 2.571

5.  The cystic fibrosis gene: isolation and significance.

Authors:  F S Collins; J R Riordan; L C Tsui
Journal:  Hosp Pract (Off Ed)       Date:  1990-10-15

6.  Misclassification of smoking habits as a source of bias in the study of environmental tobacco smoke and lung cancer.

Authors:  P N Lee; B A Forey
Journal:  Stat Med       Date:  1996-03-30       Impact factor: 2.373

Review 7.  The TDT and other family-based tests for linkage disequilibrium and association.

Authors:  R S Spielman; W J Ewens
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

8.  Molecular and statistical approaches to the detection and correction of errors in genotype databases.

Authors:  L M Brzustowicz; C Mérette; X Xie; L Townsend; T C Gilliam; J Ott
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

9.  SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

Authors:  E R Martin; E H Lai; J R Gilbert; A R Rogala; A J Afshari; J Riley; K L Finch; J F Stevens; K J Livak; B D Slotterbeck; S H Slifer; L L Warren; P M Conneally; D E Schmechel; I Purvis; M A Pericak-Vance; A D Roses; J M Vance
Journal:  Am J Hum Genet       Date:  2000-06-21       Impact factor: 11.025

10.  Misclassification in a matched case-control study with variable matching ratio: application to a study of c-erbB-2 overexpression and breast cancer.

Authors:  Stephen W Duffy; Thomas E Rohan; Rita Kandel; Teresa C Prevost; Kenneth Rice; Jonathan P Myles
Journal:  Stat Med       Date:  2003-08-15       Impact factor: 2.373
View more
  51 in total

1.  Assessing the impact of non-differential genotyping errors on rare variant tests of association.

Authors:  Scott Powers; Shyam Gopalakrishnan; Nathan Tintle
Journal:  Hum Hered       Date:  2011-10-15       Impact factor: 0.444

2.  Allelic variation in cell wall candidate genes affecting solid wood properties in natural populations and land races of Pinus radiata.

Authors:  S K Dillon; M Nolan; W Li; C Bell; H X Wu; S G Southerton
Journal:  Genetics       Date:  2010-05-24       Impact factor: 4.562

3.  Identification of genetic risk factors underlying complex multifactorial phenotypes.

Authors:  Michael Posthumus; Alison September; Martin P Schwellnus; Malcolm Collins
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2010-09-25       Impact factor: 4.342

4.  The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity.

Authors:  Inna G Ovsyannikova; Iana H Haralambieva; Robert A Vierkant; V Shane Pankratz; Robert M Jacobson; Gregory A Poland
Journal:  Hum Genet       Date:  2011-03-19       Impact factor: 4.132

5.  Optimal two-stage design for case-control association analysis incorporating genotyping errors.

Authors:  Y Zuo; G Zou; J Wang; H Zhao; H Liang
Journal:  Ann Hum Genet       Date:  2008-01-23       Impact factor: 1.670

6.  Smarter clustering methods for SNP genotype calling.

Authors:  Yan Lin; George C Tseng; Soo Yeon Cheong; Lora J H Bean; Stephanie L Sherman; Eleanor Feingold
Journal:  Bioinformatics       Date:  2008-09-29       Impact factor: 6.937

Review 7.  Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.

Authors:  Gregory A Poland; Inna G Ovsyannikova; Richard B Kennedy; Iana H Haralambieva; Robert M Jacobson
Journal:  OMICS       Date:  2011-07-06

8.  Genotyping error detection in samples of unrelated individuals without replicate genotyping.

Authors:  Nianjun Liu; Dabao Zhang; Hongyu Zhao
Journal:  Hum Hered       Date:  2008-12-15       Impact factor: 0.444

9.  Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood.

Authors:  Carol A Wise; Xiaochong Gao; Scott Shoemaker; Derek Gordon; John A Herring
Journal:  Curr Genomics       Date:  2008-03       Impact factor: 2.236

10.  Inferring linkage disequilibrium from non-random samples.

Authors:  Minghui Wang; Tianye Jia; Ning Jiang; Lin Wang; Xiaohua Hu; Zewei Luo
Journal:  BMC Genomics       Date:  2010-05-26       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.