Literature DB >> 15789548

Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination.

Peter Gebhardt1, Udo Gräfe, Ute Möllmann, Christian Hertweck.   

Abstract

A small library of leucomycin A7 derivatives was prepared by NaCNBH3/ZnCl2-mediated reductive amination of the C18 aldehyde moiety with a variety of lipophilic benzylamines and tested for antibiotic activity.

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Year:  2005        PMID： 15789548     DOI： 10.1007/s11030-005-1304-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  20 in total

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5.  Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.

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7.  Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics.

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Authors:  Y Tsuda; K Wanaka; M Tada; S Okamoto; A Hijikata-Okunomiya; Y Okada
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9.  Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens.

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  1 in total

1.  Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels-Alder reactions.

Authors:  Baiyuan Yang; Tina Zöllner; Peter Gebhardt; Ute Möllmann; Marvin J Miller
Journal:  Org Biomol Chem       Date:  2009-12-11       Impact factor: 3.876
  1 in total

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