| Literature DB >> 10986080 |
L T Phan1, R F Clark, M Rupp, Y S Or, D T Chu, Z Ma.
Abstract
A novel class of 2-fluoro-6-O-propargyl-11,12-carbamate ketolide derivatives of erythromycin has been synthesized for antibacterial SAR studies. Replacement of the C2-hydrogen by a fluorine atom allows the synthesis of 6-O-propargylic ketones and electron-deficient 6-O-propargylic aromatic derivatives by preventing intramolecular C2-enolate Michael cyclization.Entities:
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Year: 2000 PMID： 10986080 DOI： 10.1021/ol006226o
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005