| Literature DB >> 10782693 |
R F Clark1, Z Ma, S Wang, G Griesgraber, M Tufano, H Yong, L Li, X Zhang, A M Nilius, D T Chu, Y S Or.
Abstract
A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.Entities:
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Year: 2000 PMID： 10782693 DOI： 10.1016/s0960-894x(00)00106-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823