Literature DB >> 12723941

Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens.

Robert F Keyes1, Justin J Carter, Erika E Englund, Melissa M Daly, Greg G Stone, Angela M Nilius, Zhenkun Ma.   

Abstract

A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens. Promising in vitro antibacterial activity was demonstrated for compounds bearing this structural motif.

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Year:  2003        PMID： 12723941     DOI： 10.1021/jm025580k

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination.

Authors:  Peter Gebhardt; Udo Gräfe; Ute Möllmann; Christian Hertweck
Journal:  Mol Divers       Date:  2005       Impact factor: 2.943

2.  Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

Authors:  Beatriz Llano-Sotelo; Jack Dunkle; Dorota Klepacki; Wen Zhang; Prabhavathi Fernandes; Jamie H D Cate; Alexander S Mankin
Journal:  Antimicrob Agents Chemother       Date:  2010-09-20       Impact factor: 5.191

3.  Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives.

Authors:  Zhonghui Zheng; Deping Du; Lili Cao; Jun Liu; Xiaofang Chen
Journal:  J Antibiot (Tokyo)       Date:  2016-04-27       Impact factor: 2.649

4.  Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis.

Authors:  Marios G Krokidis; Viter Márquez; Daniel N Wilson; Dimitrios L Kalpaxis; George P Dinos
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191
  4 in total

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