Literature DB >> 15765130

Learning from failure: congestive heart failure in the postgenomic age.

Ivor J Benjamin1, Michael D Schneider.   

Abstract

The prognosis of heart failure is worse than that of most cancers, but new therapeutic interventions using stem and other cell-based therapies are succeeding in the fight against it, and old drugs, with new twists, are making a comeback. Genetically engineered animal models are driving insights into the molecular mechanisms that cause hearts to fail, accelerating drug discoveries, and inspiring cell-based therapeutic interventions for both acquired and inheritable cardiac diseases.

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Year:  2005        PMID： 15765130      PMCID： PMC1052014          DOI： 10.1172/JCI24477

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  30 in total

1.  Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.

Authors:  Kersten M Small; Jeanne Mialet-Perez; Carrie A Seman; Cheryl T Theiss; Kari M Brown; Stephen B Liggett
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-19       Impact factor: 11.205

2.  Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin.

Authors:  Xiaolei Xu; Steffen E Meiler; Tao P Zhong; Manzoor Mohideen; Dane A Crossley; Warren W Burggren; Mark C Fishman
Journal:  Nat Genet       Date:  2002-01-14       Impact factor: 38.330

3.  Naturally occurring variation in cardiovascular traits among inbred mouse strains.

Authors:  Brian D Hoit; Songsak Kiatchoosakun; Joseph Restivo; Darryl Kirkpatrick; Keith Olszens; Haifeng Shao; Yoh-Han Pao; Joseph H Nadeau
Journal:  Genomics       Date:  2002-05       Impact factor: 5.736

4.  Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study.

Authors:  Gysèle S Bleumink; Anneke M Knetsch; Miriam C J M Sturkenboom; Sabine M J M Straus; Albert Hofman; Jaap W Deckers; Jacqueline C M Witteman; Bruno H Ch Stricker
Journal:  Eur Heart J       Date:  2004-09       Impact factor: 29.983

5.  Hypoxia affects mesoderm and enhances hemangioblast specification during early development.

Authors:  Diana L Ramírez-Bergeron; Anja Runge; Karen D Cowden Dahl; Hans Joerg Fehling; Gordon Keller; M Celeste Simon
Journal:  Development       Date:  2004-09       Impact factor: 6.868

6.  The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.

Authors:  Amato J Giaccia; M Celeste Simon; Randall Johnson
Journal:  Genes Dev       Date:  2004-09-15       Impact factor: 11.361

Review 7.  Genetically modified mouse models for pharmacogenomic research.

Authors:  Stephen B Liggett
Journal:  Nat Rev Genet       Date:  2004-09       Impact factor: 53.242

8.  Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.

Authors:  Kobra Haghighi; Fotis Kolokathis; Luke Pater; Roy A Lynch; Michio Asahi; Anthony O Gramolini; Guo-Chang Fan; Dimitris Tsiapras; Harvey S Hahn; Stamatis Adamopoulos; Stephen B Liggett; Gerald W Dorn; David H MacLennan; Dimitrios T Kremastinos; Evangelia G Kranias
Journal:  J Clin Invest       Date:  2003-03       Impact factor: 14.808

9.  Genetic dissection of complex traits with chromosome substitution strains of mice.

Authors:  Jonathan B Singer; Annie E Hill; Lindsay C Burrage; Keith R Olszens; Junghan Song; Monica Justice; William E O'Brien; David V Conti; John S Witte; Eric S Lander; Joseph H Nadeau
Journal:  Science       Date:  2004-03-18       Impact factor: 47.728

10.  A public gene trap resource for mouse functional genomics.

Authors:  William C Skarnes; Harald von Melchner; Wolfgang Wurst; Geoff Hicks; Alex S Nord; Tony Cox; Stephen G Young; Patricia Ruiz; Phil Soriano; Marc Tessier-Lavigne; Bruce R Conklin; William L Stanford; Janet Rossant
Journal:  Nat Genet       Date:  2004-06       Impact factor: 38.330
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  18 in total

1.  Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses.

Authors:  Gabriele Multhoff; Antonio De Maio
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

Review 2.  Systems biology and heart failure: concepts, methods, and potential research applications.

Authors:  Kirkwood F Adams
Journal:  Heart Fail Rev       Date:  2010-07       Impact factor: 4.214

Review 3.  Uncoupling proteins in heart failure.

Authors:  Karl R Laskowski; Raymond R Russell
Journal:  Curr Heart Fail Rep       Date:  2008-06

Review 4.  Heart failure: advances through genomics.

Authors:  Esther E Creemers; Arthur A Wilde; Yigal M Pinto
Journal:  Nat Rev Genet       Date:  2011-03-22       Impact factor: 53.242

Review 5.  Diastolic ventricular support with cardiac support devices: an alternative approach to prevent adverse ventricular remodeling.

Authors:  Pavan Atluri; Michael A Acker
Journal:  Heart Fail Rev       Date:  2013-01       Impact factor: 4.214

6.  Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice.

Authors:  Namakkal S Rajasekaran; Matthew A Firpo; Brett A Milash; Robert B Weiss; Ivor J Benjamin
Journal:  Physiol Genomics       Date:  2008-07-15       Impact factor: 3.107

7.  Abnormal calcium "sparks" in cardiomyocytes of post-myocardial infarction heart.

Authors:  Kai Huang; Dan Huang; Shengquan Fu; Chongzhe Yang; Yuhua Liao
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2008-08-15

8.  Using systems biology approaches to understand cardiac inflammation and extracellular matrix remodeling in the setting of myocardial infarction.

Authors:  Omid Ghasemi; Yonggang Ma; Merry L Lindsey; Yu-Fang Jin
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2014 Jan-Feb

Review 9.  Animal models of dilated cardiomyopathy for translational research.

Authors:  F A Recchia; V Lionetti
Journal:  Vet Res Commun       Date:  2007-08       Impact factor: 2.459

10.  Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.

Authors:  Namakkal S Rajasekaran; Patrice Connell; Elisabeth S Christians; Liang-Jun Yan; Ryan P Taylor; András Orosz; Xiu Q Zhang; Tamara J Stevenson; Ronald M Peshock; Jane A Leopold; William H Barry; Joseph Loscalzo; Shannon J Odelberg; Ivor J Benjamin
Journal:  Cell       Date:  2007-08-10       Impact factor: 41.582
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