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Literature DB >> 18765077

Uncoupling proteins in heart failure.

Abstract

The development of heart failure is associated with alterations in the expression of a wide variety of structural, signaling, and metabolic proteins. One such effect is the downregulation of uncoupling proteins in the setting of heart failure. This group of proteins regulates the mitochondrial membrane potential and therefore plays a role in mitochondrial energy metabolism as well as reactive oxygen species generation by the mitochondria. This review discusses the role of uncoupling proteins in regulating oxidant stress and implications with respect to the pathogenesis of heart failure and potential treatments.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18765077 PMCID： PMC2692351 DOI： 10.1007/s11897-008-0013-1

Source DB: PubMed Journal: Curr Heart Fail Rep ISSN： 1546-9530

49 in total

Review 1. The failing heart--an engine out of fuel.

Authors: Stefan Neubauer
Journal: N Engl J Med Date: 2007-03-15 Impact factor: 91.245

Review 2. Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.

Authors: Pierre Douette; Francis E Sluse
Journal: Free Radic Biol Med Date: 2006-01-06 Impact factor: 7.376

Review 3. Emerging therapies for the management of decompensated heart failure: from bench to bedside.

Authors: Emil M deGoma; Randall H Vagelos; Michael B Fowler; Euan A Ashley
Journal: J Am Coll Cardiol Date: 2006-11-28 Impact factor: 24.094

Review 4. Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance.

Authors: Michael N Sack
Journal: Cardiovasc Res Date: 2006-07-21 Impact factor: 10.787

5. Association of uncoupling protein-2 expression with increased reactive oxygen species in residual myocardium of the enlarged left ventricle after myocardial infarction.

Authors: Peng Guo; Katsufumi Mizushige; Takahisa Noma; Kazushi Murakami; Tsunetatsu Namba; Makoto Ishizawa; Teppei Tsuji; Shoji Kimura; Masakazu Kohno
Journal: Heart Vessels Date: 2005-03 Impact factor: 2.037

Review 6. Learning from failure: congestive heart failure in the postgenomic age.

Authors: Ivor J Benjamin; Michael D Schneider
Journal: J Clin Invest Date: 2005-03 Impact factor: 14.808

Review 7. Oxygen, oxidative stress, hypoxia, and heart failure.

Authors: Frank J Giordano
Journal: J Clin Invest Date: 2005-03 Impact factor: 14.808

8. Oxidative stress causes heart failure with impaired mitochondrial respiration.

Authors: Hidetoshi Nojiri; Takahiko Shimizu; Masabumi Funakoshi; Osamu Yamaguchi; Heying Zhou; Satoru Kawakami; Yutaka Ohta; Manabu Sami; Toshiaki Tachibana; Hiroshi Ishikawa; Hisashi Kurosawa; Ronald C Kahn; Kinya Otsu; Takuji Shirasawa
Journal: J Biol Chem Date: 2006-09-06 Impact factor: 5.157

9. Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium.

Authors: Flora Sam; David L Kerstetter; David R Pimental; Suresh Mulukutla; Arash Tabaee; Michael R Bristow; Wilson S Colucci; Douglas B Sawyer
Journal: J Card Fail Date: 2005-08 Impact factor: 5.712

10. Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia.

Authors: Christopher J McLeod; Abdulhameed Aziz; Robert F Hoyt; J Philip McCoy; Michael N Sack
Journal: J Biol Chem Date: 2005-08-03 Impact factor: 5.157

17 in total

Review 1. Mitochondria and heart failure: new insights into an energetic problem.

Authors: L Chen; A A Knowlton
Journal: Minerva Cardioangiol Date: 2010-04 Impact factor: 1.347

2. Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart.

Authors: Hongwei Jin; Robert D Nass; Paul J Joudrey; Alexander R Lyon; Elie R Chemaly; Kleopatra Rapti; Fadi G Akar
Journal: Biophys J Date: 2010-05-19 Impact factor: 4.033

3. Congestive heart failure: where homeostasis begets dyshomeostasis.

Authors: German Kamalov; Syamal K Bhattacharya; Karl T Weber
Journal: J Cardiovasc Pharmacol Date: 2010-09 Impact factor: 3.105

4. Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure.

Authors: Michael Schwarzer; Moritz Osterholt; Anne Lunkenbein; Andrea Schrepper; Paulo Amorim; Torsten Doenst
Journal: J Physiol Date: 2014-06-20 Impact factor: 5.182

Review 5. New insights into insulin resistance in the diabetic heart.

Authors: Susan Gray; Jason K Kim
Journal: Trends Endocrinol Metab Date: 2011-06-15 Impact factor: 12.015

Review 6. Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention?

Authors: Fadi G Akar
Journal: J Interv Card Electrophysiol Date: 2013-07-04 Impact factor: 1.900

7. Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.

Authors: Amadou K S Camara; Martin Bienengraeber; David F Stowe
Journal: Front Physiol Date: 2011-04-12 Impact factor: 4.566

Review 8. Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure.

Authors: Stephen J Greene; Hani N Sabbah; Javed Butler; Adriaan A Voors; Barbara E Albrecht-Küpper; Hans-Dirk Düngen; Wilfried Dinh; Mihai Gheorghiade
Journal: Heart Fail Rev Date: 2016-01 Impact factor: 4.214

9. Chronic therapy with a partial adenosine A1-receptor agonist improves left ventricular function and remodeling in dogs with advanced heart failure.

Authors: Hani N Sabbah; Ramesh C Gupta; Smita Kohli; Mengjun Wang; Sharad Rastogi; Kefei Zhang; Katja Zimmermann; Nicole Diedrichs; Barbara E Albrecht-Küpper
Journal: Circ Heart Fail Date: 2013-04-05 Impact factor: 8.790

Review 10. Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.

Authors: Alexander T Akhmedov; Vitalyi Rybin; José Marín-García
Journal: Heart Fail Rev Date: 2015-03 Impact factor: 4.214