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Literature DB >> 21423240

Heart failure: advances through genomics.

Esther E Creemers¹, Arthur A Wilde, Yigal M Pinto.

Abstract

Heart failure is an increasingly prevalent and highly lethal disease that is most often caused by underlying pathologies, such as myocardial infarction or hypertension, but it can also be the result of a single gene mutation. Comprehensive genetic and genomic approaches are starting to disentangle the diverse molecular underpinnings of both forms of the disease and promise to yield much-needed novel diagnostic and therapeutic options for specific subtypes of heart failure.

Entities: Disease

Mesh：

Year: 2011 PMID： 21423240 DOI： 10.1038/nrg2983

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

48 in total

1. ChIP-Seq identification of weakly conserved heart enhancers.

Authors: Matthew J Blow; David J McCulley; Zirong Li; Tao Zhang; Jennifer A Akiyama; Amy Holt; Ingrid Plajzer-Frick; Malak Shoukry; Crystal Wright; Feng Chen; Veena Afzal; James Bristow; Bing Ren; Brian L Black; Edward M Rubin; Axel Visel; Len A Pennacchio
Journal: Nat Genet Date: 2010-08-22 Impact factor: 38.330

2. Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.

Authors: B M Mayosi; A Kardos; C H Davies; F Gumedze; A Hovnanian; S Burge; H Watkins
Journal: Heart Date: 2005-04-21 Impact factor: 5.994

3. LNA-mediated microRNA silencing in non-human primates.

Authors: Joacim Elmén; Morten Lindow; Sylvia Schütz; Matthew Lawrence; Andreas Petri; Susanna Obad; Marie Lindholm; Maj Hedtjärn; Henrik Frydenlund Hansen; Urs Berger; Steven Gullans; Phil Kearney; Peter Sarnow; Ellen Marie Straarup; Sakari Kauppinen
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

4. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

Authors: Nicholas L Smith; Janine F Felix; Alanna C Morrison; Serkalem Demissie; Nicole L Glazer; Laura R Loehr; L Adrienne Cupples; Abbas Dehghan; Thomas Lumley; Wayne D Rosamond; Wolfgang Lieb; Fernando Rivadeneira; Joshua C Bis; Aaron R Folsom; Emelia Benjamin; Yurii S Aulchenko; Talin Haritunians; David Couper; Joanne Murabito; Ying A Wang; Bruno H Stricker; John S Gottdiener; Patricia P Chang; Thomas J Wang; Kenneth M Rice; Albert Hofman; Susan R Heckbert; Ervin R Fox; Christopher J O'Donnell; Andre G Uitterlinden; Jerome I Rotter; James T Willerson; Daniel Levy; Cornelia M van Duijn; Bruce M Psaty; Jacqueline C M Witteman; Eric Boerwinkle; Ramachandran S Vasan
Journal: Circ Cardiovasc Genet Date: 2010-05-05

Review 5. Differential gene expression profiling in genetic and multifactorial cardiovascular diseases.

Authors: Luisa Nanni; Chiara Romualdi; Attilio Maseri; Gerolamo Lanfranchi
Journal: J Mol Cell Cardiol Date: 2006-10-03 Impact factor: 5.000

Review 6. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart.

Authors: Esther E Creemers; Yigal M Pinto
Journal: Cardiovasc Res Date: 2010-09-28 Impact factor: 10.787

7. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy.

Authors: Blanche Schroen; Stephane Heymans; Umesh Sharma; W Matthijs Blankesteijn; Saraswati Pokharel; Jack P M Cleutjens; J Gordon Porter; Chris T A Evelo; Rudy Duisters; Rick E W van Leeuwen; Ben J A Janssen; Jacques J M Debets; Jos F M Smits; Mat J A P Daemen; Harry J G M Crijns; Paul Bornstein; Yigal M Pinto
Journal: Circ Res Date: 2004-07-29 Impact factor: 17.367

Review 8. Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.

Authors: Gary E Shull; Gbolahan Okunade; Lynne H Liu; Peter Kozel; Muthu Periasamy; John N Lorenz; Vikram Prasad
Journal: Ann N Y Acad Sci Date: 2003-04 Impact factor: 5.691

9. Genetic evaluation of cardiomyopathy--a Heart Failure Society of America practice guideline.

Authors: Ray E Hershberger; Joann Lindenfeld; Luisa Mestroni; Christine E Seidman; Matthew R G Taylor; Jeffrey A Towbin
Journal: J Card Fail Date: 2009-03 Impact factor: 5.712

Review 10. Long-range control of gene expression: emerging mechanisms and disruption in disease.

Authors: Dirk A Kleinjan; Veronica van Heyningen
Journal: Am J Hum Genet Date: 2004-11-17 Impact factor: 11.025

31 in total

Review 1. Epigenetics of the failing heart.

Authors: José Marín-García; Alexander T Akhmedov
Journal: Heart Fail Rev Date: 2015-07 Impact factor: 4.214

2. HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy.

Authors: Yanjun Lai; Shuai He; Liming Ma; Hong Lin; Biyun Ren; Jing Ma; Xinyu Zhu; Shifang Zhuang
Journal: Mol Cell Biochem Date: 2017-03-18 Impact factor: 3.396

Heart failure: advances through genomics.

1. ChIP-Seq identification of weakly conserved heart enhancers.

2. Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure.

3. LNA-mediated microRNA silencing in non-human primates.

4. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

Review 5. Differential gene expression profiling in genetic and multifactorial cardiovascular diseases.

Review 6. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart.

7. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy.

Review 8. Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.

9. Genetic evaluation of cardiomyopathy--a Heart Failure Society of America practice guideline.

Review 10. Long-range control of gene expression: emerging mechanisms and disruption in disease.

Review 1. Epigenetics of the failing heart.

2. HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy.

Review 3. The Genetic Challenges and Opportunities in Advanced Heart Failure.

Review 4. Cardiac molecular imaging to track left ventricular remodeling in heart failure.

Review 5. Systems-based approaches to cardiovascular disease.

Review 6. Epigenetic mechanisms in heart development and disease.

Review 7. Genetics of common forms of heart failure: challenges and potential solutions.

8. Sparse simultaneous signal detection for identifying genetically controlled disease genes.

9. lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis.

Review 10. Heart failure in congenital heart disease: a confluence of acquired and congenital.