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Literature DB >> 15371333

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.

Amato J Giaccia¹, M Celeste Simon, Randall Johnson.

Abstract

The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2004 PMID： 15371333 PMCID： PMC517513 DOI： 10.1101/gad.1243304

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

70 in total

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Journal: Annu Rev Pharmacol Toxicol Date: 2000 Impact factor: 13.820

2. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia.

Authors: T Minamino; H Christou; C M Hsieh; Y Liu; V Dhawan; N G Abraham; M A Perrella; S A Mitsialis; S Kourembanas
Journal: Proc Natl Acad Sci U S A Date: 2001-07-10 Impact factor: 11.205

3. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.

Authors: P Carrero; K Okamoto; P Coumailleau; S O'Brien; H Tanaka; L Poellinger
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

4. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

Authors: D M Aebersold; P Burri; K T Beer; J Laissue; V Djonov; R H Greiner; G L Semenza
Journal: Cancer Res Date: 2001-04-01 Impact factor: 12.701

5. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.

Authors: M Ohh; C W Park; M Ivan; M A Hoffman; T Y Kim; L E Huang; N Pavletich; V Chau; W G Kaelin
Journal: Nat Cell Biol Date: 2000-07 Impact factor: 28.824

6. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation.

Authors: T Minamino; S Kourembanas
Journal: Circ Res Date: 2001-08-03 Impact factor: 17.367

7. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

Authors: Y Fujio; T Nguyen; D Wencker; R N Kitsis; K Walsh
Journal: Circulation Date: 2000-02-15 Impact factor: 29.690

8. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo.

Authors: W Miao; Z Luo; R N Kitsis; K Walsh
Journal: J Mol Cell Cardiol Date: 2000-12 Impact factor: 5.000

9. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling.

Authors: J Peng; L Zhang; L Drysdale; G H Fong
Journal: Proc Natl Acad Sci U S A Date: 2000-07-18 Impact factor: 11.205

10. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

Authors: V H Haase; J N Glickman; M Socolovsky; R Jaenisch
Journal: Proc Natl Acad Sci U S A Date: 2001-02-13 Impact factor: 11.205

149 in total

1. Hypoxia elicits broad and systematic changes in protein subcellular localization.

Authors: Robert Michael Henke; Ranita Ghosh Dastidar; Ajit Shah; Daniela Cadinu; Xiao Yao; Jagmohan Hooda; Li Zhang
Journal: Am J Physiol Cell Physiol Date: 2011-07-13 Impact factor: 4.249

2. Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis.

Authors: Dirk Schmidt; Björn Textor; Oliver T Pein; Alexander H Licht; Sven Andrecht; Melanie Sator-Schmitt; Norbert E Fusenig; Peter Angel; Marina Schorpp-Kistner
Journal: EMBO J Date: 2007-01-25 Impact factor: 11.598

Review 3. Direct tissue analysis by matrix-assisted laser desorption ionization mass spectrometry: application to kidney biology.

Authors: Kristen D Herring; Stacey R Oppenheimer; Richard M Caprioli
Journal: Semin Nephrol Date: 2007-11 Impact factor: 5.299

4. Oxygen Sensing Difluoroboron β-Diketonate Polylactide Materials with Tunable Dynamic Ranges for Wound Imaging.

Authors: Christopher A DeRosa; Scott A Seaman; Alexander S Mathew; Catherine M Gorick; Ziyi Fan; James N Demas; Shayn M Peirce; Cassandra L Fraser
Journal: ACS Sens Date: 2016-11-14 Impact factor: 7.711

5. MicroRNA-423 may regulate diabetic vasculopathy.

Authors: Arnon Blum; Ari Meerson; Hanan Rohana; Hanin Jabaly; Nahul Nahul; Dorina Celesh; Olga Romanenko; Snait Tamir
Journal: Clin Exp Med Date: 2019-08-17 Impact factor: 3.984

6. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.

Authors: Pasquale Fasanaro; Yuri D'Alessandra; Valeria Di Stefano; Roberta Melchionna; Sveva Romani; Giulio Pompilio; Maurizio C Capogrossi; Fabio Martelli
Journal: J Biol Chem Date: 2008-04-16 Impact factor: 5.157