Literature DB >> 15738400

Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes.

Viktor Stolc1, Manoj Pratim Samanta, Waraporn Tongprasit, Wallace F Marshall.   

Abstract

The important role that cilia and flagella play in human disease creates an urgent need to identify genes involved in ciliary assembly and function. The strong and specific induction of flagellar-coding genes during flagellar regeneration in Chlamydomonas reinhardtii suggests that transcriptional profiling of such cells would reveal new flagella-related genes. We have conducted a genome-wide analysis of RNA transcript levels during flagellar regeneration in Chlamydomonas by using maskless photolithography method-produced DNA oligonucleotide microarrays with unique probe sequences for all exons of the 19,803 predicted genes. This analysis represents previously uncharacterized whole-genome transcriptional activity profiling study in this important model organism. Analysis of strongly induced genes reveals a large set of known flagellar components and also identifies a number of important disease-related proteins as being involved with cilia and flagella, including the zebrafish polycystic kidney genes Qilin, Reptin, and Pontin, as well as the testis-expressed tubby-like protein TULP2.

Entities:  

Keywords:  NASA Center ARC; NASA Discipline Cell Biology; NASA Program Fundamental Space Biology

Mesh：

Substances：

Year:  2005        PMID： 15738400      PMCID： PMC553310          DOI： 10.1073/pnas.0408358102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  BLAT--the BLAST-like alignment tool.

Authors:  W James Kent
Journal:  Genome Res       Date:  2002-04       Impact factor: 9.043

2.  Subunits of the chaperonin CCT are associated with Tetrahymena microtubule structures and are involved in cilia biogenesis.

Authors:  Cecília Seixas; Cristina Casalou; Luís Viseu Melo; Sofia Nolasco; Pedro Brogueira; Helena Soares
Journal:  Exp Cell Res       Date:  2003-11-01       Impact factor: 3.905

3.  Light-directed 5'-->3' synthesis of complex oligonucleotide microarrays.

Authors:  Thomas J Albert; Jason Norton; Markus Ott; Todd Richmond; Kate Nuwaysir; Emile F Nuwaysir; Klaus-Peter Stengele; Roland D Green
Journal:  Nucleic Acids Res       Date:  2003-04-01       Impact factor: 16.971

Review 4.  Tubby proteins: the plot thickens.

Authors:  Kilpatrick Carroll; Carlos Gomez; Lawrence Shapiro
Journal:  Nat Rev Mol Cell Biol       Date:  2004-01       Impact factor: 94.444

Review 5.  Intraflagellar transport and cilia-dependent diseases.

Authors:  Gregory J Pazour; Joel L Rosenbaum
Journal:  Trends Cell Biol       Date:  2002-12       Impact factor: 20.808

6.  Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis.

Authors:  Tomer Avidor-Reiss; Andreia M Maer; Edmund Koundakjian; Andrey Polyanovsky; Thomas Keil; Shankar Subramaniam; Charles S Zuker
Journal:  Cell       Date:  2004-05-14       Impact factor: 41.582

7.  Genomic analysis of gene expression in C. elegans.

Authors:  A A Hill; C P Hunter; B T Tsung; G Tucker-Kellogg; E L Brown
Journal:  Science       Date:  2000-10-27       Impact factor: 47.728

8.  An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experiments.

Authors:  X Shirley Liu; Douglas L Brutlag; Jun S Liu
Journal:  Nat Biotechnol       Date:  2002-07-08       Impact factor: 54.908

9.  Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents.

Authors:  Geoff W Birrell; James A Brown; H Irene Wu; Guri Giaever; Angela M Chu; Ronald W Davis; J Martin Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-19       Impact factor: 11.205

Review 10.  The vertebrate primary cilium is a sensory organelle.

Authors:  Gregory J Pazour; George B Witman
Journal:  Curr Opin Cell Biol       Date:  2003-02       Impact factor: 8.382
View more
  98 in total

Review 1.  Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.

Authors:  Maureen Wirschell; Ryosuke Yamamoto; Lea Alford; Avanti Gokhale; Anne Gaillard; Winfield S Sale
Journal:  Arch Biochem Biophys       Date:  2011-04-14       Impact factor: 4.013

Review 2.  Cilia in vertebrate development and disease.

Authors:  Edwin C Oh; Nicholas Katsanis
Journal:  Development       Date:  2012-02       Impact factor: 6.868

3.  Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.

Authors:  C Laligné; C Klotz; N Garreau de Loubresse; M Lemullois; M Hori; F X Laurent; J F Papon; B Louis; J Cohen; F Koll
Journal:  Eukaryot Cell       Date:  2010-01-29

4.  Genetic and genomic approaches to identify genes involved in flagellar assembly in Chlamydomonas reinhardtii.

Authors:  Huawen Lin; Susan K Dutcher
Journal:  Methods Cell Biol       Date:  2015-02-14       Impact factor: 1.441

5.  The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.

Authors:  Melissa K Jungnickel; Keith A Sutton; Mark A Baker; Michael G Cohen; Michael J Sanderson; Harvey M Florman
Journal:  Biol Reprod       Date:  2018-10-01       Impact factor: 4.285

6.  The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.

Authors:  Narendra Pathak; Tomoko Obara; Steve Mangos; Yan Liu; Iain A Drummond
Journal:  Mol Biol Cell       Date:  2007-08-29       Impact factor: 4.138

7.  Flagellar elongation and gene expression in Chlamydomonas reinhardtii.

Authors:  Goran Periz; Darshita Dharia; Steven H Miller; Laura R Keller
Journal:  Eukaryot Cell       Date:  2007-06-15

8.  C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia.

Authors:  Mahmoud R Fassad; Amelia Shoemark; Pierrick le Borgne; France Koll; Mitali Patel; Mellisa Dixon; Jane Hayward; Charlotte Richardson; Emily Frost; Lucy Jenkins; Thomas Cullup; Eddie M K Chung; Michel Lemullois; Anne Aubusson-Fleury; Claire Hogg; David R Mitchell; Anne-Marie Tassin; Hannah M Mitchison
Journal:  Am J Hum Genet       Date:  2018-05-03       Impact factor: 11.025

9.  Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas.

Authors:  Karin van Dijk; Katherine E Marley; Byeong-ryool Jeong; Jianping Xu; Jennifer Hesson; Ronald L Cerny; Jakob H Waterborg; Heriberto Cerutti
Journal:  Plant Cell       Date:  2005-08-12       Impact factor: 11.277

10.  Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.

Authors:  Christina Austin-Tse; Jan Halbritter; Maimoona A Zariwala; Renée M Gilberti; Heon Yung Gee; Nathan Hellman; Narendra Pathak; Yan Liu; Jennifer R Panizzi; Ramila S Patel-King; Douglas Tritschler; Raqual Bower; Eileen O'Toole; Jonathan D Porath; Toby W Hurd; Moumita Chaki; Katrina A Diaz; Stefan Kohl; Svjetlana Lovric; Daw-Yang Hwang; Daniela A Braun; Markus Schueler; Rannar Airik; Edgar A Otto; Margaret W Leigh; Peadar G Noone; Johnny L Carson; Stephanie D Davis; Jessica E Pittman; Thomas W Ferkol; Jeffry J Atkinson; Kenneth N Olivier; Scott D Sagel; Sharon D Dell; Margaret Rosenfeld; Carlos E Milla; Niki T Loges; Heymut Omran; Mary E Porter; Stephen M King; Michael R Knowles; Iain A Drummond; Friedhelm Hildebrandt
Journal:  Am J Hum Genet       Date:  2013-10-03       Impact factor: 11.025
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.