Literature DB >> 21513695

Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.

Maureen Wirschell1, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S Sale.   

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21513695      PMCID： PMC3114296          DOI： 10.1016/j.abb.2011.04.003

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  177 in total

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Journal:  Cell       Date:  2004-05-14       Impact factor: 41.582

2.  Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex.

Authors:  Janine M Bekker; Jessica R Colantonio; Andrew D Stephens; W Thomas Clarke; Stephen J King; Kent L Hill; Rachelle H Crosbie
Journal:  Cell Motil Cytoskeleton       Date:  2007-06

Review 3.  Control of sperm motility and fertility: diverse factors and common mechanisms.

Authors:  M Yoshida; N Kawano; K Yoshida
Journal:  Cell Mol Life Sci       Date:  2008-11       Impact factor: 9.261

Review 4.  From promiscuity to precision: protein phosphatases get a makeover.

Authors:  David M Virshup; Shirish Shenolikar
Journal:  Mol Cell       Date:  2009-03-13       Impact factor: 17.970

5.  The Chlamydomonas PF6 locus encodes a large alanine/proline-rich polypeptide that is required for assembly of a central pair projection and regulates flagellar motility.

Authors:  G Rupp; E O'Toole; M E Porter
Journal:  Mol Biol Cell       Date:  2001-03       Impact factor: 4.138

6.  cAMP-stimulated phosphorylation of an axonemal polypeptide that copurifies with the 22S dynein arm regulates microtubule translocation velocity and swimming speed in Paramecium.

Authors:  T Hamasaki; K Barkalow; J Richmond; P Satir
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

7.  Cilia with defective radial spokes: a cause of human respiratory disease.

Authors:  J M Sturgess; J Chao; J Wong; N Aspin; J A Turner
Journal:  N Engl J Med       Date:  1979-01-11       Impact factor: 91.245

8.  Direction of active sliding of microtubules in Tetrahymena cilia.

Authors:  W S Sale; P Satir
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

9.  Localization of calmodulin and dynein light chain LC8 in flagellar radial spokes.

Authors:  P Yang; D R Diener; J L Rosenbaum; W S Sale
Journal:  J Cell Biol       Date:  2001-06-11       Impact factor: 10.539

10.  Intracellular Ca2+ regulates the phosphorylation and the dephosphorylation of ciliary proteins via the NO pathway.

Authors:  Irena Gertsberg; Vardit Hellman; Michal Fainshtein; Simy Weil; Shai D Silberberg; Michael Danilenko; Zvi Priel
Journal:  J Gen Physiol       Date:  2004-10-11       Impact factor: 4.086
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  33 in total

1.  Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.

Authors:  Thomas Heuser; Cynthia F Barber; Jianfeng Lin; Jeremy Krell; Matthew Rebesco; Mary E Porter; Daniela Nicastro
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

2.  Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.

Authors:  Miquel Tuson; Mu He; Kathryn V Anderson
Journal:  Development       Date:  2011-10-17       Impact factor: 6.868

3.  Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.

Authors:  M Cifuentes; V Baeza; P M Arrabal; R Visser; J M Grondona; N Saldivia; F Martínez; F Nualart; K Salazar
Journal:  Mol Neurobiol       Date:  2017-02-13       Impact factor: 5.590

4.  The Chlamydomonas mutant pf27 reveals novel features of ciliary radial spoke assembly.

Authors:  Lea M Alford; Alexa L Mattheyses; Emily L Hunter; Huawen Lin; Susan K Dutcher; Winfield S Sale
Journal:  Cytoskeleton (Hoboken)       Date:  2013-12

Review 5.  The Central Apparatus of Cilia and Eukaryotic Flagella.

Authors:  Thomas D Loreng; Elizabeth F Smith
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-02-01       Impact factor: 10.005

6.  A Structural Basis for How Motile Cilia Beat.

Authors:  Peter Satir; Thomas Heuser; Winfield S Sale
Journal:  Bioscience       Date:  2014-11-25       Impact factor: 8.589

7.  Methods to measure and analyze ciliary beat activity: Ca2+ influx-mediated cilia mechanosensitivity.

Authors:  Wen-Er Li; Weiwei Chen; Yun-Fei Ma; Qing-Rong Tuo; Xiao-Jing Luo; Ting Zhang; Wen-Bo Sai; Jing Liu; Jinhua Shen; Zhi-Gang Liu; Yun-Min Zheng; Yong-Xiao Wang; Guangju Ji; Qing-Hua Liu
Journal:  Pflugers Arch       Date:  2012-10-05       Impact factor: 3.657

8.  Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex.

Authors:  Long Gui; Kangkang Song; Douglas Tritschler; Raqual Bower; Si Yan; Aguang Dai; Katherine Augspurger; Jason Sakizadeh; Magdalena Grzemska; Thomas Ni; Mary E Porter; Daniela Nicastro
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-28       Impact factor: 11.205

9.  Alcohol-induced ciliary dysfunction targets the outer dynein arm.

Authors:  Fan Yang; Jacqueline Pavlik; Laura Fox; Chasity Scarbrough; Winfield S Sale; Joseph H Sisson; Maureen Wirschell
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-01-16       Impact factor: 5.464

10.  Subcellular localization and function of mouse radial spoke protein 3 in mammalian cells and central nervous system.

Authors:  Xinde Hu; Runchuan Yan; Lingzhen Song; Xi Lu; Shulin Chen; Shanting Zhao
Journal:  J Mol Histol       Date:  2014-07-31       Impact factor: 2.611
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