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Literature DB >> 12495842

Intraflagellar transport and cilia-dependent diseases.

Abstract

Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.

Entities: Disease Species

Mesh：

Year: 2002 PMID： 12495842 DOI： 10.1016/s0962-8924(02)02410-8

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

122 in total

Review 1. Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment.

Authors: Qicong Hu; W James Nelson
Journal: Cytoskeleton (Hoboken) Date: 2011-06-10

2. New insights into ciliary function: kidney cysts and photoreceptors.

Authors: James P Calvet
Journal: Proc Natl Acad Sci U S A Date: 2003-05-05 Impact factor: 11.205

3. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport.

Authors: Yuqing Hou; Gregory J Pazour; George B Witman
Journal: Mol Biol Cell Date: 2004-07-21 Impact factor: 4.138

4. Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella.

Authors: Benjamin D Engel; Karl-Ferdinand Lechtreck; Tsuyoshi Sakai; Mitsuo Ikebe; George B Witman; Wallace F Marshall
Journal: Methods Cell Biol Date: 2009-12-04 Impact factor: 1.441

5. Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.

Authors: Melanie Brunnbauer; Felix Mueller-Planitz; Süleyman Kösem; Thi Hieu Ho; Renate Dombi; J Christof M Gebhardt; Matthias Rief; Zeynep Okten
Journal: Proc Natl Acad Sci U S A Date: 2010-05-24 Impact factor: 11.205

6. IFT46 plays an essential role in cilia development.

Authors: Mi-Sun Lee; Kyu-Seok Hwang; Hyun-Woo Oh; Kim Ji-Ae; Hyun-Taek Kim; Hyun-Soo Cho; Jeong-Ju Lee; Je Yeong Ko; Jung-Hwa Choi; Yun-Mi Jeong; Kwan-Hee You; Joon Kim; Doo-Sang Park; Ki-Hoan Nam; Shinichi Aizawa; Hiroshi Kiyonari; Go Shioi; Jong-Hoon Park; Weibin Zhou; Nam-Soon Kim; Cheol-Hee Kim
Journal: Dev Biol Date: 2015-02-24 Impact factor: 3.582

Intraflagellar transport and cilia-dependent diseases.

Review 1. Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment.

2. New insights into ciliary function: kidney cysts and photoreceptors.

3. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport.

4. Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella.

5. Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.

6. IFT46 plays an essential role in cilia development.

Review 7. Speculations on the evolution of 9+2 organelles and the role of central pair microtubules.

8. Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice.

9. RC/BTB2 is essential for formation of primary cilia in mammalian cells.

10. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.