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Literature DB >> 15691976

High-level acetaldehyde production in Lactococcus lactis by metabolic engineering.

Roger S Bongers¹, Marcel H N Hoefnagel, Michiel Kleerebezem.

Abstract

Efficient conversion of glucose to acetaldehyde is achieved by nisin-controlled overexpression of Zymomonas mobilis pyruvate decarboxylase (pdc) and Lactococcus lactis NADH oxidase (nox) in L. lactis. In resting cells, almost 50% of the glucose consumed could be redirected towards acetaldehyde by combined overexpression of pdc and nox under anaerobic conditions.

Entities: Chemical Species

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Year: 2005 PMID： 15691976 PMCID： PMC546684 DOI： 10.1128/AEM.71.2.1109-1113.2005

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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