Literature DB >> 10966436

Lactococcus lactis as a cell factory for high-level diacetyl production.

J Hugenholtz1, M Kleerebezem, M Starrenburg, J Delcour, W de Vos, P Hols.   

Abstract

We report the engineering of Lactococcus lactis for the efficient conversion of sugar into diacetyl by combining NADH-oxidase overproduction and alpha-acetolactate decarboxylase inactivation. Eighty percent of the carbon flux was found to be rerouted via alpha-acetolactate to the production of diacetyl by preloading the cells with NADH-oxidase before their use as a cell factory.

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Year:  2000        PMID： 10966436      PMCID： PMC92266          DOI： 10.1128/AEM.66.9.4112-4114.2000

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  10 in total

1.  Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp. lactis bv. diacetylactis.

Authors:  J L Snoep; M J Teixeira de Mattos; M J Starrenburg; J Hugenholtz
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

2.  Isolation and properties of Lactococcus lactis subsp. lactis biovar diacetylactis CNRZ 483 mutants producing diacetyl and acetoin from glucose.

Authors:  H Boumerdassi; C Monnet; M Desmazeaud; G Corrieu
Journal:  Appl Environ Microbiol       Date:  1997-06       Impact factor: 4.792

3.  Cloning, expression, and characterization of the Lactococcus lactis pfl gene, encoding pyruvate formate-lyase.

Authors:  J Arnau; F Jørgensen; S M Madsen; A Vrang; H Israelsen
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

4.  Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl-overproducing strains.

Authors:  N Goupil; G Corthier; S D Ehrlich; P Renault
Journal:  Appl Environ Microbiol       Date:  1996-07       Impact factor: 4.792

5.  Genetic manipulation of the pathway for diacetyl metabolism in Lactococcus lactis.

Authors:  S R Swindell; K H Benson; H G Griffin; P Renault; S D Ehrlich; M J Gasson
Journal:  Appl Environ Microbiol       Date:  1996-07       Impact factor: 4.792

6.  Antimicrobial properties of diacetyl.

Authors:  J M Jay
Journal:  Appl Environ Microbiol       Date:  1982-09       Impact factor: 4.792

7.  A general method for selection of alpha-acetolactate decarboxylase-deficient Lactococcus lactis mutants to improve diacetyl formation.

Authors:  M Curic; B Stuer-Lauridsen; P Renault; D Nilsson
Journal:  Appl Environ Microbiol       Date:  1999-03       Impact factor: 4.792

8.  Cofactor engineering: a novel approach to metabolic engineering in Lactococcus lactis by controlled expression of NADH oxidase.

Authors:  F Lopez de Felipe; M Kleerebezem; W M de Vos; J Hugenholtz
Journal:  J Bacteriol       Date:  1998-08       Impact factor: 3.490

9.  Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.

Authors:  P G de Ruyter; O P Kuipers; W M de Vos
Journal:  Appl Environ Microbiol       Date:  1996-10       Impact factor: 4.792

10.  Metabolic engineering of Lactococcus lactis: influence of the overproduction of alpha-acetolactate synthase in strains deficient in lactate dehydrogenase as a function of culture conditions.

Authors:  C Platteeuw; J Hugenholtz; M Starrenburg; I van Alen-Boerrigter; W M de Vos
Journal:  Appl Environ Microbiol       Date:  1995-11       Impact factor: 4.792
  10 in total
  26 in total

1.  Expression of plant flavor genes in Lactococcus lactis.

Authors:  Igor Hernández; Douwe Molenaar; Jules Beekwilder; Harro Bouwmeester; Johan E T van Hylckama Vlieg
Journal:  Appl Environ Microbiol       Date:  2007-01-05       Impact factor: 4.792

Review 2.  Physiological and Transcriptional Responses of Different Industrial Microbes at Near-Zero Specific Growth Rates.

Authors:  Onur Ercan; Markus M M Bisschops; Wout Overkamp; Thomas R Jørgensen; Arthur F Ram; Eddy J Smid; Jack T Pronk; Oscar P Kuipers; Pascale Daran-Lapujade; Michiel Kleerebezem
Journal:  Appl Environ Microbiol       Date:  2015-06-05       Impact factor: 4.792

3.  Citrate metabolism by Enterococcus faecalis FAIR-E 229.

Authors:  P Sarantinopoulos; G Kalantzopoulos; E Tsakalidou
Journal:  Appl Environ Microbiol       Date:  2001-12       Impact factor: 4.792

4.  Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance.

Authors:  Ana Rute Neves; Ana Ramos; Helena Costa; Iris I van Swam; Jeroen Hugenholtz; Michiel Kleerebezem; Willem de Vos; Helena Santos
Journal:  Appl Environ Microbiol       Date:  2002-12       Impact factor: 4.792

5.  In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments.

Authors:  Bas Teusink; Frank H J van Enckevort; Christof Francke; Anne Wiersma; Arno Wegkamp; Eddy J Smid; Roland J Siezen
Journal:  Appl Environ Microbiol       Date:  2005-11       Impact factor: 4.792

6.  High-level acetaldehyde production in Lactococcus lactis by metabolic engineering.

Authors:  Roger S Bongers; Marcel H N Hoefnagel; Michiel Kleerebezem
Journal:  Appl Environ Microbiol       Date:  2005-02       Impact factor: 4.792

7.  Diacetyl and acetoin production from whey permeate using engineered Lactobacillus casei.

Authors:  Inmaculada Nadal; Juan Rico; Gaspar Pérez-Martínez; María J Yebra; Vicente Monedero
Journal:  J Ind Microbiol Biotechnol       Date:  2009-07-16       Impact factor: 3.346

8.  IS981-mediated adaptive evolution recovers lactate production by ldhB transcription activation in a lactate dehydrogenase-deficient strain of Lactococcus lactis.

Authors:  Roger S Bongers; Marcel H N Hoefnagel; Marjo J C Starrenburg; Marco A J Siemerink; John G A Arends; Jeroen Hugenholtz; Michiel Kleerebezem
Journal:  J Bacteriol       Date:  2003-08       Impact factor: 3.490

9.  Increased production of folate by metabolic engineering of Lactococcus lactis.

Authors:  Wilbert Sybesma; Marjo Starrenburg; Michiel Kleerebezem; Igor Mierau; Willem M de Vos; Jeroen Hugenholtz
Journal:  Appl Environ Microbiol       Date:  2003-06       Impact factor: 4.792

10.  Production of functionalized biopolyester granules by recombinant Lactococcus lactis.

Authors:  Jun Mifune; Katrin Grage; Bernd H A Rehm
Journal:  Appl Environ Microbiol       Date:  2009-05-22       Impact factor: 4.792
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