Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue.

There have been extensive observations that RNA containing repetitive elements accumulates in transformed cells and tumor tissues. In the present study, we first obtained result consistent with previous observations by in situ hybridization. Then we used primer extension analysis to determine the level of polymerase III directed Alu RNA and found an increased expression of Alu RNA in hepatocellular carcinoma. Copyright 2004 Wiley-Liss, Inc.