Literature DB >> 24222357

The perinucleolar compartment: RNA metabolism and cancer.

John T Norton1, Sui Huang.   

Abstract

The perinucleolar compartment (PNC) is a nuclear substructure associated with, but structurally distinct from, the nucleolus. The PNC contains several RNA processing proteins and several RNA pol III transcripts, which form novel complexes. As determined by cell culture experiments and human tumor samples, the PNC forms exclusively in cancer cells and the percentage of cancer cells in a population that have one or more PNCs directly correlates with the malignancy of that population of cells. Therefore, the PNC is being developed as a prognostic marker for several malignancies. PNC elimination in cancer cells has proven to be a useful as screening method to discover probe compounds used to elucidate PNC biology and to discover compounds with the potential to be developed as minimally toxic anti-cancer drugs.

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Year:  2013        PMID： 24222357      PMCID： PMC4374481          DOI： 10.1007/978-3-642-31659-3_6

Source DB:  PubMed          Journal:  Cancer Treat Res        ISSN： 0927-3042


  38 in total

1.  Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue.

Authors:  Rui-Bao Tang; Hong-Yang Wang; Hai-Ying Lu; Jun Xiong; Hong-Hua Li; Xiu-Hua Qiu; Hou-Qi Liu
Journal:  Mol Carcinog       Date:  2005-02       Impact factor: 4.784

2.  Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades.

Authors:  Ji-eun Oh; Karlin Raja Karlmark; Joo-ho Shin; Arnold Pollak; Angelika Freilinger; Markus Hengstschläger; Gert Lubec
Journal:  Neurochem Res       Date:  2005-03       Impact factor: 3.996

3.  Perinucleolar compartment prevalence has an independent prognostic value for breast cancer.

Authors:  Rajesh V Kamath; Ann D Thor; Chen Wang; Susan M Edgerton; Alicja Slusarczyk; D J Leary; J Wang; E L Wiley; B Jovanovic; Q Wu; R Nayar; P Kovarik; F Shi; Sui Huang
Journal:  Cancer Res       Date:  2005-01-01       Impact factor: 12.701

Review 4.  Intracellular localization and nucleocytoplasmic transport of Ro RNP components.

Authors:  G J Pruijn; F H Simons; W J van Venrooij
Journal:  Eur J Cell Biol       Date:  1997-10       Impact factor: 4.492

5.  Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.

Authors:  L T Timchenko; J W Miller; N A Timchenko; D R DeVore; K V Datar; L Lin; R Roberts; C T Caskey; M S Swanson
Journal:  Nucleic Acids Res       Date:  1996-11-15       Impact factor: 16.971

6.  Initiation of mitochondrial DNA replication by transcription and R-loop processing.

Authors:  D Y Lee; D A Clayton
Journal:  J Biol Chem       Date:  1998-11-13       Impact factor: 5.157

7.  Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.

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Journal:  Clin Cancer Res       Date:  1996-09       Impact factor: 12.531

8.  The dynamic organization of the perinucleolar compartment in the cell nucleus.

Authors:  S Huang; T J Deerinck; M H Ellisman; D L Spector
Journal:  J Cell Biol       Date:  1997-06-02       Impact factor: 10.539

9.  The perinucleolar compartment and transcription.

Authors:  S Huang; T J Deerinck; M H Ellisman; D L Spector
Journal:  J Cell Biol       Date:  1998-10-05       Impact factor: 10.539

10.  A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I.

Authors:  A G Matera; M R Frey; K Margelot; S L Wolin
Journal:  J Cell Biol       Date:  1995-06       Impact factor: 10.539
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  7 in total

1.  A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival.

Authors:  Karen Yap; Svetlana Mukhina; Gen Zhang; Jason S C Tan; Hong Sheng Ong; Eugene V Makeyev
Journal:  Mol Cell       Date:  2018-10-11       Impact factor: 17.970

Review 2.  Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways.

Authors:  Dariusz Stępiński
Journal:  Histochem Cell Biol       Date:  2016-05-03       Impact factor: 4.304

3.  Metabolism and pharmacokinetics characterization of metarrestin in multiple species.

Authors:  Elias C Padilha; Pranav Shah; Amy Q Wang; Marc D Singleton; Emma A Hughes; Dandan Li; Kelly A Rice; Kylie M Konrath; Samarjit Patnaik; Juan Marugan; Udo Rudloff; Xin Xu
Journal:  Cancer Chemother Pharmacol       Date:  2020-03-17       Impact factor: 3.333

4.  Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.

Authors:  Kazuaki Tokunaga; Noriko Saitoh; Ilya G Goldberg; Chiyomi Sakamoto; Yoko Yasuda; Yoshinori Yoshida; Shinya Yamanaka; Mitsuyoshi Nakao
Journal:  Sci Rep       Date:  2014-11-11       Impact factor: 4.379

Review 5.  LncRNAs divide and rule: The master regulators of phase separation.

Authors:  Kumaravel Somasundaram; Bhavana Gupta; Nishkarsh Jain; Samarjit Jana
Journal:  Front Genet       Date:  2022-08-10       Impact factor: 4.772

6.  Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.

Authors:  Tomas Vilimas; Amy Q Wang; Samarjit Patnaik; Emma A Hughes; Marc D Singleton; Zachary Knotts; Dandan Li; Kevin Frankowski; Jerome J Schlomer; Theresa M Guerin; Stephanie Springer; Catherine Drennan; Christopher Dextras; Chen Wang; Debra Gilbert; Noel Southall; Marc Ferrer; Sui Huang; Serguei Kozlov; Juan Marugan; Xin Xu; Udo Rudloff
Journal:  Cancer Chemother Pharmacol       Date:  2018-10-10       Impact factor: 3.333

7.  A small molecule inhibitor of the perinucleolar compartment, ML246, attenuates growth and spread of ovarian cancer.

Authors:  Margaux J Kanis; Wenan Qiang; Mario Pineda; Kruti P Maniar; J Julie Kim
Journal:  Gynecol Oncol Res Pract       Date:  2018-10-02
  7 in total

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