Literature DB >> 15192699

Histone variant H2ABbd confers lower stability to the nucleosome.

Thierry Gautier1, D Wade Abbott, Annie Molla, Andre Verdel, Juan Ausio, Stefan Dimitrov.   

Abstract

The histone H2ABbd is a novel histone variant of H2A with a totally unknown function. We have investigated the behaviour of the H2ABbd nucleosomes. Nucleosomes were reconstituted with recombinant histone H2ABbd and changes in their conformations at different salt concentrations were studied by analytical centrifugation. The data are in agreement with H2ABbd being less tightly bound compared with conventional H2A in the nucleosome. In addition, stable cell lines expressing either green fluorescent protein (GFP)-H2A or GFP-H2ABbd were established and the mobility of both fusions was measured by fluorescence recovery after photobleaching. We show that GFP-H2ABbd exchanges much more rapidly than GFP-H2A within the nucleosome. The reported data are compatible with a lower stability of the variant H2ABbd nucleosome compared with the conventional H2A particle.

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Year:  2004        PMID： 15192699      PMCID： PMC1299093          DOI： 10.1038/sj.embor.7400182

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  32 in total

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Review 4.  Studying protein dynamics in living cells.

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5.  Preferential interaction of the core histone tail domains with linker DNA.

Authors:  D Angelov; J M Vitolo; V Mutskov; S Dimitrov; J J Hayes
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

Review 6.  The many tales of a tail: carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin function.

Authors:  Juan Ausió; D Wade Abbott
Journal:  Biochemistry       Date:  2002-05-14       Impact factor: 3.162

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Authors:  B P Chadwick; H F Willard
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  54 in total

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Review 2.  Histone variants in metazoan development.

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Review 4.  Histone structure and nucleosome stability.

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8.  Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome.

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Journal:  EMBO J       Date:  2006-09-07       Impact factor: 11.598

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Review 10.  Role of chromatin states in transcriptional memory.

Authors:  Sharmistha Kundu; Craig L Peterson
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