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Literature DB >> 1518086

A statistical test of hypotheses on the organization and origin of the genetic code.

Abstract

Theories of the origin of the genetic code assign different weights to amino acid properties such as polarity and precursor-product relationship. Previous statistical work on the origin of the genetic code has produced controversial results. We analyze relationships between various amino acid and tRNA properties by one and the same statistical method. It is shown that polarities as well as precursor-product relationships are both likely to have been important in shaping the genetic code, together with codon swapping that left protein sequences intact.

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Year: 1992 PMID： 1518086 DOI： 10.1007/bf00178593

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

16 in total

9. An interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices.

Authors: Blazej Bulka; Marie desJardins; Stephen J Freeland
Journal: BMC Bioinformatics Date: 2006-07-03 Impact factor: 3.169

9 in total

A statistical test of hypotheses on the organization and origin of the genetic code.

1. An anticodon change switches the identity of E. coli tRNA(mMet) from methionine to threonine.

2. A quantitative measure of error minimization in the genetic code.

3. What do languages tell us about human microevolution?

Review 4. Evolution of the genetic code as affected by anticodon content.

5. How old is the genetic code? Statistical geometry of tRNA provides an answer.

6. Codon reassignment (codon capture) in evolution.

7. The molecular basis for the genetic code.

8. Role of minimization of chemical distances between amino acids in the evolution of the genetic code.

9. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.

10. The detection of disease clustering and a generalized regression approach.

Review 1. The case for an error minimizing standard genetic code.

2. No accident: genetic codes freeze in error-correcting patterns of the standard genetic code.

3. On concerted origin of transfer RNAs with complementary anticodons.

4. The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code.

5. The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code.

6. Further results on error minimization in the genetic code.

7. The phylogeny of tRNA molecules and the origin of the genetic code.

8. The presence of codon-anticodon pairs in the acceptor stem of tRNAs.

9. An interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices.