Literature DB >> 2109304

An anticodon change switches the identity of E. coli tRNA(mMet) from methionine to threonine.

L H Schulman1, H Pelka.   

Abstract

Recent evidence indicates that the anticodon may often play a crucial role in selection of tRNAs by aminoacyl-tRNA synthetases. In order to quantitate the contribution of the anticodon to discrimination between cognate and noncognate tRNAs by E. coli threonyl-tRNA synthetase, derivatives of the E. coli elongator methionine tRNA (tRNA(mMet)) containing wild type and threonine anticodons have been synthesized in vitro and assayed for threonine acceptor activity. Substitution of the threonine anticodon GGU for the methionine anticodon CAU increased the threonine acceptor activity of tRNA(mMet) by four orders of magnitude while reducing methionine acceptor activity by an even greater amount. These results indicate that the anticodon is the major element which determines the identity of both threonine and methionine tRNAs.

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Year:  1990        PMID： 2109304      PMCID： PMC330265          DOI： 10.1093/nar/18.2.285

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  33 in total

1.  Anticodon switching changes the identity of methionine and valine transfer RNAs.

Authors:  L H Schulman; H Pelka
Journal:  Science       Date:  1988-11-04       Impact factor: 47.728

2.  Translational control in E. coli: the case of threonyl-tRNA synthetase.

Authors:  M Springer; M Graffe; J Dondon; M Grunberg-Manago; P Romby; B Ehresmann; C Ehresmann; J P Ebel
Journal:  Biosci Rep       Date:  1988-12       Impact factor: 3.840

Review 3.  tRNA identity.

Authors:  J Normanly; J Abelson
Journal:  Annu Rev Biochem       Date:  1989       Impact factor: 23.643

4.  Loss of methionine acceptor activity resulting from a base change in the anticodon of Escherichia coli formylmethionine transfer ribonucleic acid.

Authors:  L H Schulman; J P Goddard
Journal:  J Biol Chem       Date:  1973-02-25       Impact factor: 5.157

5.  Factors determining the specificity of the tRNA aminoacylation reaction. Non-absolute specificity of tRNA-aminoacyl-tRNA synthetase recognition and particular importance of the maximal velocity.

Authors:  J P Ebel; R Giegé; J Bonnet; D Kern; N Befort; C Bollack; F Fasiolo; J Gangloff; G Dirheimer
Journal:  Biochimie       Date:  1973-05       Impact factor: 4.079

6.  Inactivation of valine acceptor ativity by a C-U missense change in the anticodon of yeast valine transfer ribonucleic acid.

Authors:  R W Chambers; S Aoyagi; Y Furukawa; H Zawadzka; O S Bhanot
Journal:  J Biol Chem       Date:  1973-08-10       Impact factor: 5.157

7.  Primary structure of a methionine transfer RNA from Escherichia coli.

Authors:  S Cory; K A Marcker; S K Dube; B F Clark
Journal:  Nature       Date:  1968-12-07       Impact factor: 49.962

8.  Normal and mutant glycine transfer RNAs.

Authors:  C Squires; J Carbon
Journal:  Nat New Biol       Date:  1971-10-27

9.  Messenger RNA structure and gene regulation at the translational level in Escherichia coli: the case of threonine:tRNAThr ligase.

Authors:  H Moine; P Romby; M Springer; M Grunberg-Manago; J P Ebel; C Ehresmann; B Ehresmann
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  tRNA-like structures and gene regulation at the translational level: a case of molecular mimicry in Escherichia coli.

Authors:  M Springer; M Graffe; J Dondon; M Grunberg-Manago
Journal:  EMBO J       Date:  1989-08       Impact factor: 11.598
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  20 in total

1.  A statistical test of hypotheses on the organization and origin of the genetic code.

Authors:  E Szathmáry; E Zintzaras
Journal:  J Mol Evol       Date:  1992-09       Impact factor: 2.395

2.  Identity determinants of E. coli tryptophan tRNA.

Authors:  H Himeno; T Hasegawa; H Asahara; K Tamura; M Shimizu
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971

3.  Enzymatic aminoacylation of sequence-specific RNA minihelices and hybrid duplexes with methionine.

Authors:  S A Martinis; P Schimmel
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

4.  Conversion of aminoacylation specificity from tRNA(Tyr) to tRNA(Ser) in vitro.

Authors:  H Himeno; T Hasegawa; T Ueda; K Watanabe; M Shimizu
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

5.  Aminoacyl-tRNA synthetase-induced cleavage of tRNA.

Authors:  S Beresten; M Jahn; D Söll
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

6.  Evolution of tRNA recognition systems and tRNA gene sequences.

Authors:  M E Saks; J R Sampson
Journal:  J Mol Evol       Date:  1995-05       Impact factor: 2.395

7.  Porcine E-selectin: cloning and functional characterization.

Authors:  Y T Tsang; P E Stephens; S T Licence; D O Haskard; R M Binns; M K Robinson
Journal:  Immunology       Date:  1995-05       Impact factor: 7.397

8.  Molecular mimicry in translational control of E. coli threonyl-tRNA synthetase gene. Competitive inhibition in tRNA aminoacylation and operator-repressor recognition switch using tRNA identity rules.

Authors:  P Romby; C Brunel; J Caillet; M Springer; M Grunberg-Manago; E Westhof; C Ehresmann; B Ehresmann
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

Review 9.  Functions of the gene products of Escherichia coli.

Authors:  M Riley
Journal:  Microbiol Rev       Date:  1993-12

10.  In vitro study of E.coli tRNA(Arg) and tRNA(Lys) identity elements.

Authors:  K Tamura; H Himeno; H Asahara; T Hasegawa; M Shimizu
Journal:  Nucleic Acids Res       Date:  1992-05-11       Impact factor: 16.971
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