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Literature DB >> 15070731

Mammalian GLD-2 homologs are poly(A) polymerases.

Jae Eun Kwak¹, Liaoteng Wang, Scott Ballantyne, Judith Kimble, Marvin Wickens.

Abstract

GLD-2 is a cytoplasmic poly(A) polymerase present in the Caenorhabditis elegans germ line and embryo. It is a divergent member of the DNA polymerase beta nucleotidyl transferase superfamily, which includes CCA-adding enzymes, DNA polymerases and eukaryotic nuclear poly(A) polymerases. The polyadenylation activity of GLD-2 is stimulated by physical interaction with an RNA binding protein, GLD-3. To test whether GLD-3 might stimulate GLD-2 by recruiting it to RNA, we tethered C. elegans GLD-2 to mRNAs in Xenopus oocytes by using MS2 coat protein. Tethered GLD-2 adds poly(A) and stimulates translation of the mRNA, demonstrating that recruitment is sufficient to stimulate polyadenylation activity. We use the same tethered assay to identify human and mouse poly(A) polymerases related to GLD-2. This may provide entrees to previously uncharacterized modes of polyadenylation in mammalian cells.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15070731 PMCID： PMC384760 DOI： 10.1073/pnas.0400779101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

47 in total

Review 1. RNA polymerase II and the integration of nuclear events.

Authors: Y Hirose; J L Manley
Journal: Genes Dev Date: 2000-06-15 Impact factor: 11.361

2. Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.

Authors: S Kashiwabara; T Zhuang; K Yamagata; J Noguchi; A Fukamizu; T Baba
Journal: Dev Biol Date: 2000-12-01 Impact factor: 3.582

Review 3. Local protein synthesis and its role in synapse-specific plasticity.

Authors: K C Martin; M Barad; E R Kandel
Journal: Curr Opin Neurobiol Date: 2000-10 Impact factor: 6.627

4. Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.

Authors: G Martin; W Keller; S Doublié
Journal: EMBO J Date: 2000-08-15 Impact factor: 11.598

Review 5. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.

Authors: C Patil; P Walter
Journal: Curr Opin Cell Biol Date: 2001-06 Impact factor: 8.382

Review 6. The ends of the affair: capping and polyadenylation.

Authors: A J Shatkin; J L Manley
Journal: Nat Struct Biol Date: 2000-10

7. A novel nuclear human poly(A) polymerase (PAP), PAP gamma.

Authors: C B Kyriakopoulou; H Nordvarg; A Virtanen
Journal: J Biol Chem Date: 2001-06-28 Impact factor: 5.157

8. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors.

Authors: S L Topalian; S Kaneko; M I Gonzales; G L Bond; Y Ward; J L Manley
Journal: Mol Cell Biol Date: 2001-08 Impact factor: 4.272

9. Multiple portions of poly(A)-binding protein stimulate translation in vivo.

Authors: N K Gray; J M Coller; K S Dickson; M Wickens
Journal: EMBO J Date: 2000-09-01 Impact factor: 11.598

10. Poly(A) polymerase and the regulation of cytoplasmic polyadenylation.

Authors: K S Dickson; S R Thompson; N K Gray; M Wickens
Journal: J Biol Chem Date: 2001-09-10 Impact factor: 5.157

71 in total

1. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.

Authors: Rafal Tomecki; Aleksandra Dmochowska; Kamil Gewartowski; Andrzej Dziembowski; Piotr P Stepien
Journal: Nucleic Acids Res Date: 2004-11-16 Impact factor: 16.971

2. The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.

Authors: Aikaterini Rapti; Theoni Trangas; Martina Samiotaki; Panayotis Ioannidis; Euthymios Dimitriadis; Christos Meristoudis; Stavroula Veletza; Nelly Courtis
Journal: Mol Cell Biochem Date: 2010-02-21 Impact factor: 3.396

Mammalian GLD-2 homologs are poly(A) polymerases.

Review 1. RNA polymerase II and the integration of nuclear events.

2. Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.

Review 3. Local protein synthesis and its role in synapse-specific plasticity.

4. Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.

Review 5. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.

Review 6. The ends of the affair: capping and polyadenylation.

7. A novel nuclear human poly(A) polymerase (PAP), PAP gamma.

8. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors.

9. Multiple portions of poly(A)-binding protein stimulate translation in vivo.

10. Poly(A) polymerase and the regulation of cytoplasmic polyadenylation.

1. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.

2. The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.

3. Under the Tucson sun: a meeting in the desert on mRNA decay.

4. Autoregulation of GLD-2 cytoplasmic poly(A) polymerase.

5. Fission yeast Cid12 has dual functions in chromosome segregation and checkpoint control.

6. Yeast Trf5p is a nuclear poly(A) polymerase.

7. A family of poly(U) polymerases.

Review 8. RNA-specific ribonucleotidyl transferases.

9. Terminal RNA uridylyltransferases of trypanosomes.

Review 10. New ways to meet your (3') end oligouridylation as a step on the path to destruction.