Literature DB >> 15070344

CD and MCD studies of the non-heme ferrous active site in (4-hydroxyphenyl)pyruvate dioxygenase: correlation between oxygen activation in the extradiol and alpha-KG-dependent dioxygenases.

Michael L Neidig1, Michael Kavana, Graham R Moran, Edward I Solomon.   

Abstract

(4-Hydroxyphenyl)pyruvate dioxygenase (HPPD) is an unusual alpha-keto acid-dependent non-heme iron dioxygenase as it incorporates both atoms of dioxygen into a single substrate, paralleling the extradiol dioxygenases. CD/MCD studies of the catalytically active ferrous site and its interaction with substrate reveal a geometic and electronic structure and mechanistic approach to oxygen activation which bridges those of the alpha-KG-dependent and the extradiol dioxygenases.

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Year:  2004        PMID： 15070344     DOI： 10.1021/ja0316521

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  13 in total

1.  Near-IR MCD of the nonheme ferrous active site in naphthalene 1,2-dioxygenase: correlation to crystallography and structural insight into the mechanism of Rieske dioxygenases.

Authors:  Takehiro Ohta; Sarmistha Chakrabarty; John D Lipscomb; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2008-01-12       Impact factor: 15.419

2.  Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation.

Authors:  Adrienne R Diebold; Christina D Brown-Marshall; Michael L Neidig; June M Brownlee; Graham R Moran; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2011-10-21       Impact factor: 15.419

3.  Spectroscopic and computational studies of α-keto acid binding to Dke1: understanding the role of the facial triad and the reactivity of β-diketones.

Authors:  Adrienne R Diebold; Grit D Straganz; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2011-09-14       Impact factor: 15.419

4.  Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes.

Authors:  Michael L Neidig; Andrea Decker; Oliver W Choroba; Fanglu Huang; Michael Kavana; Graham R Moran; Jonathan B Spencer; Edward I Solomon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-18       Impact factor: 11.205

5.  The three-his triad in Dke1: comparisons to the classical facial triad.

Authors:  Adrienne R Diebold; Michael L Neidig; Graham R Moran; Grit D Straganz; Edward I Solomon
Journal:  Biochemistry       Date:  2010-08-17       Impact factor: 3.162

6.  Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: intermediates formed by a tyrosine 257 variant.

Authors:  Michael M Mbughuni; Katlyn K Meier; Eckard Münck; John D Lipscomb
Journal:  Biochemistry       Date:  2012-10-29       Impact factor: 3.162

7.  CD and MCD spectroscopic studies of the two Dps miniferritin proteins from Bacillus anthracis: role of O2 and H2O2 substrates in reactivity of the diiron catalytic centers.

Authors:  Jennifer K Schwartz; Xiaofeng S Liu; Takehiko Tosha; Adrienne Diebold; Elizabeth C Theil; Edward I Solomon
Journal:  Biochemistry       Date:  2010-11-12       Impact factor: 3.162

8.  C-Term magnetic circular dichroism (MCD) spectroscopy in paramagnetic transition metal and f-element organometallic chemistry.

Authors:  Nikki J Wolford; Aleksa Radovic; Michael L Neidig
Journal:  Dalton Trans       Date:  2020-12-14       Impact factor: 4.390

Review 9.  The diverse and pervasive chemistries of the alpha-keto acid dependent enzymes.

Authors:  Vincent Purpero; Graham R Moran
Journal:  J Biol Inorg Chem       Date:  2007-04-13       Impact factor: 3.862

10.  Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.

Authors:  Linn G Bjørnstad; Giorgio Zoppellaro; Ane B Tomter; Pål Ø Falnes; K Kristoffer Andersson
Journal:  Biochem J       Date:  2011-03-15       Impact factor: 3.857
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