Literature DB >> 17431691

The diverse and pervasive chemistries of the alpha-keto acid dependent enzymes.

Vincent Purpero1, Graham R Moran.   

Abstract

The number of identified and confirmed alpha-keto acid dependent oxygenases is increasing rapidly. All of these enzymes have a relatively simple liganding arrangement for a single ferrous ion but collectively conduct a highly diverse set of chemistries. While hydroxylations and a variety of oxidation reactions have been most commonly observed, new reactions involving dealkylations, epimerizations and halogenations have recently been discovered. In this minireview we present what is known of the alpha-keto acid dependent enzymes and offer an argument that the chemistry that is unique to each enzyme occurs only after the production of a pivotal ferryl-oxo intermediate.

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Year:  2007        PMID： 17431691     DOI： 10.1007/s00775-007-0231-0

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.862


  103 in total

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4.  Resonance Raman studies of the iron(II)--alpha-keto acid chromophore in model and enzyme complexes.

Authors:  R Y Ho; M P Mehn; E L Hegg; A Liu; M J Ryle; R P Hausinger; L Que
Journal:  J Am Chem Soc       Date:  2001-05-30       Impact factor: 15.419

5.  Aberrant activity of the DNA repair enzyme AlkB.

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6.  Substrate-induced conformational changes in Escherichia coli taurine/alpha-ketoglutarate dioxygenase and insight into the oligomeric structure.

Authors:  Jessica R O'Brien; David J Schuller; Victoria S Yang; Bret D Dillard; William N Lanzilotta
Journal:  Biochemistry       Date:  2003-05-20       Impact factor: 3.162

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Journal:  J Biol Chem       Date:  1985-11-15       Impact factor: 5.157

9.  Studies on the partial reaction of thymine 7-hydroxylase in the presence of 5-fluorouracil.

Authors:  E Holme; S Lindstedt
Journal:  Biochim Biophys Acta       Date:  1982-06-04

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  31 in total

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Review 3.  Vitamins C and E: beneficial effects from a mechanistic perspective.

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7.  Copper(I)-alpha-ketocarboxylate complexes: characterization and O2 reactions that yield copper-oxygen intermediates capable of hydroxylating arenes.

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