| Literature DB >> 15036807 |
Nobuyuki Takahashi1, Oliver Smithies.
Abstract
Essential hypertension is probably caused by combinations of small quantitative changes in the expression of many genes together with environmental factors. In this article, strategies for studying hypertension using animal models are summarized with emphasis on the combined use of mouse models and computer simulations. We have chosen the rennin-angiotensin system as our main example. Future directions of hypertension research using gene targeting are also discussed.Entities:
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Year: 2004 PMID： 15036807 DOI： 10.1016/j.tig.2004.01.004
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639