Literature DB >> 14741260

Degradation of target protein in living cells by small-molecule proteolysis inducer.

Dong Zhang1, Sun Hee Baek, Abby Ho, Kyungbo Kim.   

Abstract

Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).

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Year:  2004        PMID： 14741260     DOI： 10.1016/j.bmcl.2003.11.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Impact of linker length on the activity of PROTACs.

Authors:  Kedra Cyrus; Marie Wehenkel; Eun-Young Choi; Hyeong-Jun Han; Hyosung Lee; Hollie Swanson; Kyung-Bo Kim
Journal:  Mol Biosyst       Date:  2010-10-04

Review 2.  Chemical approaches to controlling intracellular protein degradation.

Authors:  John S Schneekloth; Craig M Crews
Journal:  Chembiochem       Date:  2005-01       Impact factor: 3.164

Review 3.  Chemical inducers of targeted protein degradation.

Authors:  Kanak Raina; Craig M Crews
Journal:  J Biol Chem       Date:  2010-02-10       Impact factor: 5.157

Review 4.  Targeted Protein Degradation by Small Molecules.

Authors:  Daniel P Bondeson; Craig M Crews
Journal:  Annu Rev Pharmacol Toxicol       Date:  2016-10-12       Impact factor: 13.820

5.  Two-headed PROTAC: an effective new tool for targeted protein degradation.

Authors:  Kedra Cyrus; Marie Wehenkel; Eun-Young Choi; Hollie Swanson; Kyung-Bo Kim
Journal:  Chembiochem       Date:  2010-07-26       Impact factor: 3.164

Review 6.  Induced protein degradation: an emerging drug discovery paradigm.

Authors:  Ashton C Lai; Craig M Crews
Journal:  Nat Rev Drug Discov       Date:  2016-11-25       Impact factor: 84.694

7.  Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs.

Authors:  Kedra Cyrus; Marie Wehenkel; Eun-Young Choi; Hyosung Lee; Hollie Swanson; Kyung-Bo Kim
Journal:  ChemMedChem       Date:  2010-07-05       Impact factor: 3.466

8.  Use of PROTACS as molecular probes of angiogenesis.

Authors:  Paola Bargagna-Mohan; Sun-Hee Baek; Hyosung Lee; Kyungbo Kim; Royce Mohan
Journal:  Bioorg Med Chem Lett       Date:  2005-06-02       Impact factor: 2.823

Review 9.  Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Authors:  Philipp M Cromm; Craig M Crews
Journal:  Cell Chem Biol       Date:  2017-06-22       Impact factor: 8.116

10.  PROTAC-induced proteolytic targeting.

Authors:  Kimberly Cornish Carmony; Kyung-Bo Kim
Journal:  Methods Mol Biol       Date:  2012
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