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Literature DB >> 20572252

Two-headed PROTAC: an effective new tool for targeted protein degradation.

Kedra Cyrus¹, Marie Wehenkel¹, Eun-Young Choi², Hollie Swanson², Kyung-Bo Kim¹.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20572252 PMCID： PMC3852688 DOI： 10.1002/cbic.201000222

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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21 in total

Review 1. SCF and Cullin/Ring H2-based ubiquitin ligases.

Authors: R J Deshaies
Journal: Annu Rev Cell Dev Biol Date: 1999 Impact factor: 13.827

2. Degradation of target protein in living cells by small-molecule proteolysis inducer.

Authors: Dong Zhang; Sun Hee Baek; Abby Ho; Kyungbo Kim
Journal: Bioorg Med Chem Lett Date: 2004-02-09 Impact factor: 2.823

3. From knowing to controlling: a path from genomics to drugs using small molecule probes.

Authors: Robert L Strausberg; Stuart L Schreiber
Journal: Science Date: 2003-04-11 Impact factor: 47.728

4. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

Authors: K M Sakamoto; K B Kim; A Kumagai; F Mercurio; C M Crews; R J Deshaies
Journal: Proc Natl Acad Sci U S A Date: 2001-07-03 Impact factor: 11.205

5. Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

Authors: Yukihiro Itoh; Minoru Ishikawa; Mikihiko Naito; Yuichi Hashimoto
Journal: J Am Chem Soc Date: 2010-04-28 Impact factor: 15.419

Review 6. Trace elements in regulation of NF-kappaB activity.

Authors: A V Kudrin
Journal: J Trace Elem Med Biol Date: 2000-10 Impact factor: 3.849

7. Synthesis and evaluation of geldanamycin-testosterone hybrids.

Authors: S D Kuduk; T C Harris; F F Zheng; L Sepp-Lorenzino; Q Ouerfelli; N Rosen; S J Danishefsky
Journal: Bioorg Med Chem Lett Date: 2000-06-05 Impact factor: 2.823

8. Chemical genetic control of protein levels: selective in vivo targeted degradation.

Authors: John S Schneekloth; Fabiana N Fonseca; Michael Koldobskiy; Amit Mandal; Raymond Deshaies; Kathleen Sakamoto; Craig M Crews
Journal: J Am Chem Soc Date: 2004-03-31 Impact factor: 15.419

9. Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation.

Authors: Kathleen M Sakamoto; Kyung B Kim; Rati Verma; Andy Ransick; Bernd Stein; Craig M Crews; Raymond J Deshaies
Journal: Mol Cell Proteomics Date: 2003-10-02 Impact factor: 5.911

10. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

Authors: Shu Zhang; Chunhua Qin; Stephen H Safe
Journal: Environ Health Perspect Date: 2003-12 Impact factor: 9.031

12 in total

1. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.

Authors: Dennis L Buckley; Kanak Raina; Nicole Darricarrere; John Hines; Jeffrey L Gustafson; Ian E Smith; Afjal H Miah; John D Harling; Craig M Crews
Journal: ACS Chem Biol Date: 2015-06-23 Impact factor: 5.100

Review 2. Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Authors: Philipp M Cromm; Craig M Crews
Journal: Cell Chem Biol Date: 2017-06-22 Impact factor: 8.116

3. PROTAC-induced proteolytic targeting.

Authors: Kimberly Cornish Carmony; Kyung-Bo Kim
Journal: Methods Mol Biol Date: 2012

4. MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53.

Authors: John Hines; Schan Lartigue; Hanqing Dong; Yimin Qian; Craig M Crews
Journal: Cancer Res Date: 2018-11-01 Impact factor: 12.701