| Literature DB >> 14684334 |
Gerardo D Francisco1, Zhong Li, J Donald Albright, Nancy H Eudy, Alan H Katz, Peter J Petersen, Pornpen Labthavikul, Guy Singh, Youjun Yang, Beth A Rasmussen, Yang-I Lin, Tarek S Mansour.
Abstract
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.Entities:
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Year: 2004 PMID： 14684334 DOI： 10.1016/j.bmcl.2003.09.082
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823