Literature DB >> 14644182

Beyond A, C, G and T: augmenting nature's alphabet.

Allison A Henry1, Floyd E Romesberg.   

Abstract

Efforts to expand the genetic alphabet are predicated upon a stable and replicable third base pair. Recent progress has resulted in the development of several candidates that are both stable in duplex DNA and replicated by DNA polymerases with various degrees of efficiency and fidelity. The candidate base pairs draw upon unnatural hydrogen-bonding topologies as well as upon shape complementarity and hydrophobic forces. This review provides a critical comparison of the third base pair candidates and discusses the further work required to expand the genetic alphabet.

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Year:  2003        PMID： 14644182     DOI： 10.1016/j.cbpa.2003.10.011

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  61 in total

1.  Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a polarity sensitive probe.

Authors:  Mark M Somoza; Daniele Andreatta; Catherine J Murphy; Robert S Coleman; Mark A Berg
Journal:  Nucleic Acids Res       Date:  2004-05-06       Impact factor: 16.971

2.  Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair.

Authors:  Corinna Kaul; Markus Müller; Mirko Wagner; Sabine Schneider; Thomas Carell
Journal:  Nat Chem       Date:  2011-08-28       Impact factor: 24.427

3.  Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives.

Authors:  Gerard Hobley; Vladimir Gubala; María Del C Rivera-Sánchez; José M Rivera
Journal:  Synlett       Date:  2008-06-01       Impact factor: 2.454

Review 4.  Setting the stage: the history, chemistry, and geobiology behind RNA.

Authors:  Steven A Benner; Hyo-Joong Kim; Zunyi Yang
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-01-01       Impact factor: 10.005

5.  Measurement and theory of hydrogen bonding contribution to isosteric DNA base pairs.

Authors:  Omid Khakshoor; Steven E Wheeler; K N Houk; Eric T Kool
Journal:  J Am Chem Soc       Date:  2012-02-02       Impact factor: 15.419

6.  DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.

Authors:  Olga Potapova; Chikio Chan; Angela M DeLucia; Sandra A Helquist; Eric T Kool; Nigel D F Grindley; Catherine M Joyce
Journal:  Biochemistry       Date:  2006-01-24       Impact factor: 3.162

7.  Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix.

Authors:  Stephen R Lynch; Haibo Liu; Jianmin Gao; Eric T Kool
Journal:  J Am Chem Soc       Date:  2006-11-15       Impact factor: 15.419

8.  Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems.

Authors:  Andrew T Krueger; Haige Lu; Alex H F Lee; Eric T Kool
Journal:  Acc Chem Res       Date:  2007-02       Impact factor: 22.384

Review 9.  Directed polymerase evolution.

Authors:  Tingjian Chen; Floyd E Romesberg
Journal:  FEBS Lett       Date:  2013-11-05       Impact factor: 4.124

10.  Efficient replication bypass of size-expanded DNA base pairs in bacterial cells.

Authors:  James C Delaney; Jianmin Gao; Haibo Liu; Nidhi Shrivastav; John M Essigmann; Eric T Kool
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336
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