Literature DB >> 1683157

Non-random association between DNA markers and Huntington disease locus in the Italian population.

A Novelletto1, P Mandich, E Bellone, P Malaspina, G Vivona, F Ajmar, M Frontali.   

Abstract

A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1683157     DOI： 10.1002/ajmg.1320400326

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  4 in total

1.  Predictive testing for Huntington's disease: ten years' experience in two Italian centres.

Authors:  P Mandich; G Jacopini; E Di Maria; G Sabbadini; G Abbruzzese; F Chimirri; E Bellone; A Novelletto; F Ajmar; M Frontali
Journal:  Ital J Neurol Sci       Date:  1998-04

2.  Allelic association under map error and recombinational heterogeneity: a tale of two sites.

Authors:  C Lonjou; A Collins; R S Ajioka; L B Jorde; J P Kushner; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

3.  Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

Authors:  M I Skraastad; E Van de Vosse; R Belfroid; K Höld; M Vegter-van der Vlis; L A Sandkuijl; E Bakker; G J van Ommen
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

4.  Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

Authors:  U Thies; B Bockel; B Gerdes; K Schröder
Journal:  Hum Genet       Date:  1993-12       Impact factor: 4.132
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.