Literature DB >> 1377913

cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

G McAllister1, P Whiting, E A Hammond, M R Knowles, J R Atack, F J Bailey, R Maigetter, C I Ragan.   

Abstract

Inositol monophosphatase (EC 3.1.3.25) is a key enzyme in the phosphoinositide cell-signalling system. Its role is to provide inositol required for the resynthesis of phosphatidylinositol and polyphosphoinositides. It is the probable pharmacological target for lithium action in brain. Using probes derived from the bovine inositol monophosphatase cDNA we have isolated cDNA clones encoding the human and rat brain enzymes. The enzyme is highly conserved in all three species (79% identical). The coding region of the human cDNA was inserted into a bacterial expression vector. The expressed recombinant enzyme was purified and its biochemical properties examined. The human enzyme is very similar to the bovine enzyme.

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Year:  1992        PMID： 1377913      PMCID： PMC1132602          DOI： 10.1042/bj2840749

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate.

Authors:  C I Ragan; K J Watling; N S Gee; S Aspley; R G Jackson; G G Reid; R Baker; D C Billington; R J Barnaby; P D Leeson
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

2.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Authors:  R K Saiki; D H Gelfand; S Stoffel; S J Scharf; R Higuchi; G T Horn; K B Mullis; H A Erlich
Journal:  Science       Date:  1988-01-29       Impact factor: 47.728

Review 3.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

4.  "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

5.  Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III.

Authors:  T S Ross; J F Tait; P W Majerus
Journal:  Science       Date:  1990-05-04       Impact factor: 47.728

6.  A mutation that enhances synthesis of sigma 32 and suppresses temperature-sensitive growth of the rpoH15 mutant of Escherichia coli.

Authors:  R Yano; H Nagai; K Shiba; T Yura
Journal:  J Bacteriol       Date:  1990-04       Impact factor: 3.490

7.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

8.  The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

Authors:  L M Hallcher; W R Sherman
Journal:  J Biol Chem       Date:  1980-11-25       Impact factor: 5.157

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.

Authors:  A R Hawkins; H K Lamb; M Smith; J W Keyte; C F Roberts
Journal:  Mol Gen Genet       Date:  1988-10
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  24 in total

1.  Bovine inositol monophosphatase. Modification, identification and mutagenesis of reactive cysteine residues.

Authors:  M R Knowles; N Gee; G McAllister; C I Ragan; P J Greasley; M G Gore
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

2.  Structure of inositol monophosphatase, the putative target of lithium therapy.

Authors:  R Bone; J P Springer; J R Atack
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

3.  Characterization of a tetrameric inositol monophosphatase from the hyperthermophilic bacterium Thermotoga maritima.

Authors:  L Chen; M F Roberts
Journal:  Appl Environ Microbiol       Date:  1999-10       Impact factor: 4.792

4.  Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

Authors:  Nisha Singh; Amy C Halliday; Matthew Knight; Nathan A Lack; Edward Lowe; Grant C Churchill
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-09-22

5.  Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli.

Authors:  Greg Brown; Alexander Singer; Vladimir V Lunin; Michael Proudfoot; Tatiana Skarina; Robert Flick; Samvel Kochinyan; Ruslan Sanishvili; Andrzej Joachimiak; Aled M Edwards; Alexei Savchenko; Alexander F Yakunin
Journal:  J Biol Chem       Date:  2008-12-10       Impact factor: 5.157

6.  Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.

Authors:  Tetsuo Ohnishi; Takuya Murata; Akiko Watanabe; Akiko Hida; Hisako Ohba; Yoshimi Iwayama; Kazuo Mishima; Yoichi Gondo; Takeo Yoshikawa
Journal:  J Biol Chem       Date:  2014-02-19       Impact factor: 5.157

7.  Bovine inositol monophosphatase: enzyme-metal-ion interactions studied by pre-equilibrium fluorescence spectroscopy.

Authors:  M R Thorne; P J Greasley; M G Gore
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

8.  Inositol monophosphatase is a highly conserved enzyme having localized structural similarity to both glycerol 3-phosphate dehydrogenase and haemoglobin.

Authors:  K A Wreggett
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

9.  Barley (Hordeum vulgare L.) inositol monophosphatase: gene structure and enzyme characteristics.

Authors:  Jianming Fu; Kevin Peterson; Mary Guttieri; Edward Souza; Victor Raboy
Journal:  Plant Mol Biol       Date:  2008-05-21       Impact factor: 4.076

10.  Cloning and expression of the inositol monophosphatase gene from Methanococcus jannaschii and characterization of the enzyme.

Authors:  L Chen; M F Roberts
Journal:  Appl Environ Microbiol       Date:  1998-07       Impact factor: 4.792
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