Literature DB >> 23027737

Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

Nisha Singh1, Amy C Halliday, Matthew Knight, Nathan A Lack, Edward Lowe, Grant C Churchill.   

Abstract

Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mouse IMPase 1 (MmIMPase 1) and human IMPase 1 (HsIMPase 1) were cloned into pRSET5a, expressed in Escherichia coli, purified and crystallized using the sitting-drop method. The structures were solved at resolutions of 2.4 and 1.7 Å, respectively. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 Å.

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Year:  2012        PMID： 23027737      PMCID： PMC3497969          DOI： 10.1107/S1744309112035191

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  17 in total

1.  In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

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2.  High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy.

Authors:  Raj Gill; Fiyaz Mohammed; Rajji Badyal; Leighton Coates; Peter Erskine; Darren Thompson; Jonathan Cooper; Michael Gore; Stephen Wood
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2005-04-20

3.  iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM.

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Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-03-18

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Authors:  P Emsley; B Lohkamp; W G Scott; K Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-03-24

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Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

6.  Cloning and expression of the inositol monophosphatase gene from Methanococcus jannaschii and characterization of the enzyme.

Authors:  L Chen; M F Roberts
Journal:  Appl Environ Microbiol       Date:  1998-07       Impact factor: 4.792

7.  Mechanism of inositol monophosphatase, the putative target of lithium therapy.

Authors:  S J Pollack; J R Atack; M R Knowles; G McAllister; C I Ragan; R Baker; S R Fletcher; L L Iversen; H B Broughton
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

8.  Purification and properties of myo-inositol-1-phosphatase from rat brain.

Authors:  K Takimoto; M Okada; Y Matsuda; H Nakagawa
Journal:  J Biochem       Date:  1985-08       Impact factor: 3.387

Review 9.  Scaling and assessment of data quality.

Authors:  Philip Evans
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2005-12-14

10.  Phaser crystallographic software.

Authors:  Airlie J McCoy; Ralf W Grosse-Kunstleve; Paul D Adams; Martyn D Winn; Laurent C Storoni; Randy J Read
Journal:  J Appl Crystallogr       Date:  2007-07-13       Impact factor: 3.304
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  5 in total

1.  Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.

Authors:  Tetsuo Ohnishi; Takuya Murata; Akiko Watanabe; Akiko Hida; Hisako Ohba; Yoshimi Iwayama; Kazuo Mishima; Yoichi Gondo; Takeo Yoshikawa
Journal:  J Biol Chem       Date:  2014-02-19       Impact factor: 5.157

2.  A safe lithium mimetic for bipolar disorder.

Authors:  Nisha Singh; Amy C Halliday; Justyn M Thomas; Olga V Kuznetsova; Rhiannon Baldwin; Esther C Y Woon; Parvinder K Aley; Ivi Antoniadou; Trevor Sharp; Sridhar R Vasudevan; Grant C Churchill
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

3.  Direct Ionic Regulation of the Activity of Myo-Inositol Biosynthesis Enzymes in Mozambique Tilapia.

Authors:  Fernando D Villarreal; Dietmar Kültz
Journal:  PLoS One       Date:  2015-06-11       Impact factor: 3.240

4.  Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.

Authors:  Noelia Ferruz; Gary Tresadern; Antonio Pineda-Lucena; Gianni De Fabritiis
Journal:  Sci Rep       Date:  2016-07-21       Impact factor: 4.379

5.  Sequence-based identification of inositol monophosphatase-like histidinol-phosphate phosphatases (HisN) in Corynebacterium glutamicum, Actinobacteria, and beyond.

Authors:  Robert Kasimir Kulis-Horn; Christian Rückert; Jörn Kalinowski; Marcus Persicke
Journal:  BMC Microbiol       Date:  2017-07-18       Impact factor: 3.605
  5 in total

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